摘要
目的：探讨乳腺癌患者行保乳手术治疗后局部复发的相关因素.方法：收集2002年3月 2010年3月行保乳手术治疗的356例乳腺癌患者的临床及随访资料,分析年龄、淋巴结转移、肿瘤直径、人表皮生长因子受体2 （HER-2）、雌激素受体（ER）/孕激素受体（PR）与术后肿瘤局部复发的相关性.结果：356例患者的中位随访时间为53（9-120）个月;其中14例（4.3％）患者出现同侧乳房局部复发,16例（4.9％）出现远处转移;5年无远处转移生存率为95.4％,5年总体生存率为99.1％,5年无病生存率为82.3％;乳腺癌患者行保乳治疗手术后2-3年是肿瘤局部复发的高峰时期,单因素以及多因素分析发现,患者的年龄、淋巴结转移及HER-2是肿瘤局部复发的独立危险因素.结论：淋巴结转移以及HER-2与乳腺癌患者行保乳手术后的局部复发相关.
Objective：To explore the factors correlated to breast cancer recurrence after breast-conserving surgery.Methods：The clinical and follow-up medical data of 356 patients with breast cancer after breast-conserving surgery from March 2002 to March 2012 were collected.The correlations of age,lymph node metastasis,tumor diameter,human epidermal growth factor receptor 2 （HER-2）,estrogen receptor （ER） /progesterone receptor（PR） with postoperative tumor local recurrence were analyzed.Results：The median follow-up period was 53（9-120） months.Among the 356 cases,14 cases （4.3％） had local recurrence in ipsilateral breast,while 16 cases （4.9％） had distant metastasis.The 5-year distant metastasis-free survival rate was 95.4％.The 5-year overall survival rate was 99.1％.The 5 year disease-free survival rate was 82.3％.The peak period for local recurrences was 2-3 years after surgery.Univariate analysis and multivariate analysis demonstrated that age,lymph node metastasis and HER-2 were independent risk factors of local recurrence.Conclusions：Age,lymph node metastasis and HER-2 were correlated to local recurrence after breast conserving surgery.
出处
《中国临床医学》
2014年第4期431-432,437,共3页
Chinese Journal of Clinical Medicine
关键词
乳腺癌
复发
保乳治疗
危险因素
Breast cancer
Recurrence
Breast-conserving therapy
Risk factors
