摘要
成簇的规律间隔的短回文重复序列(clustered regularly interspacedshort palindromic repeat,CRISPR)为原核生物构建了一种抵御外源DNA侵扰的防御机制,近年来成为国内外细菌研究者们的研究热点。在介绍CRISPR系统的研究历史、分布分类、结构特征的基础上,对其作用机制以及应用前景方面进行了综述。
Clustered regularly interspaced short palindromic repeats （CRISPR）, which provides effective resistance against foreign nucleic-acid elements has become a hot spot in the research of bacteriologists both at home and abroad. On the basis of introducing the research history, distribution clsssification,structure and characteristics,the mechanism and application prospects of CRISPR-system were reviewed.
出处
《安徽农业科学》
CAS
2014年第31期10845-10847,10895,共4页
Journal of Anhui Agricultural Sciences
基金
国家自然科学基金项目(31201905)
江苏省高校优势学科建设项目
