摘要
近10年来,功能磁共振成像被广泛应用于研究恶性肿瘤治疗疗效早期评价以及良恶性淋巴结的鉴别。弥散加权磁共振成像(diffusion weighted imaging,DWI)技术是功能磁共振成像的一种,是目前唯一应用于临床的可测量人体内水分子扩散运动的方法。它通过测量活体组织内的水分子弥散运动,从而为早期评价患者对治疗的反应、良恶性淋巴结的鉴别提供重要信息。本文综述了功能磁共振尤其是弥散加权磁共振成像在恶性肿瘤早期疗效评价及淋巴结良恶性鉴别的研究进展,认为弥散加权磁共振成像技术作为一种无创性的功能成像检查方法,通过其高分辨率以及功能成像的特点在以上两方面已经显示出较PET/CT更大的优势,具有相当大的发展前景。
Over the past decade, functional magnetic resonance imaging （fMRI） has been widely used to study the early therapeutic evaluation of malignant tumor treatment and identification of benign and malignant lymph nodes. Diffusion weighted magnetic resonance imaging （DWI） technology is one of the fMRI technologies, which issensitive to the microscopic motion of water molecules and allows for noninvasive characterization of biological tissues based on their water diffusion properties. The degree of restriction of water diffusion in biological tissues is related to tissue cellularities and the integrity of cell membranes. Thus, DWI may demonstrate early changes in cancers at the cellular level, such as the breakdown of cancer cells or the distortion of the microenvironment. This paper reviews published articles concerning both the early therapeutice valuation and identification of benign and malignant lymph nodes. As a noninvasive screening method with its high resolution and functional imaging features, DWI has shown superiority compared with PET/ CT, bearing considerable development prospects.
出处
《科技导报》
CAS
CSCD
北大核心
2014年第30期35-39,共5页
Science & Technology Review
基金
国家临床重点专科建设项目单位基金项目(国卫办医函2013/544号)
湖南省肿瘤医院科研平台基金项目(PT2013-05)
关键词
放疗
热疗
弥散加权磁共振成像
早期疗效
淋巴结
radiotherapy
hyperthermia
diffusion weighted magnetic resonance imaging
response
lymph nodes
