摘要
目的探讨新疆地区维吾尔族、汉族乳腺癌患者分子分型和预后的关系。方法收集2001年1月—2008年12月新疆医科大学第一附属医院收治的汉族乳腺癌患者224例和维吾尔族乳腺癌83例的临床资料,利用免疫组织化学方法(IHC)和荧光原位杂交技术(FISH)进行分子分型,随访全组患者,运用Kaplan-Meier法研究预后。结果维吾尔族、汉族乳腺癌患者各分子分型构成比差异无统计学意义(χ2=7.382,P=0.061);中位无病生存时间:维吾尔族患者为64.5个月,汉族患者为70个月,Luminal A型为66个月,Luminal B型为66个月,ErbB2过表达型为64个月,基底样型为70个月,两民族患者的无病生存期(DFS)差异有统计学意义(P=0.004),各分子分型的DFS差异有统计学意义(P=0.024)。结论分子分型可能是判断维吾尔族、汉族乳腺癌患者的预后因素之一。
Objective To explore the relationship between molecular subtypes and prognosis of Xinjiang Uyghur and Han patients with breast cancer.Methods 307 inpatients in 2001.1-2008.12 in the First Af-filiated hospital to Xinjiang Medical University were selected,including 224 Han cases and 83 Uyghur ca-ses,and they were tested by Immunohistochemistry （IHC）and fluorescence in situ hybridization （FISH） for the molecular typing and the follow-up study was conducted;the prognosis was studied by Kaplan-Meier method.Results There were no statistically significant differences in constituent ratios of molecular subtypes between Uyghur and Han groups （χ2 =7.382,P =0.061）.The results of prognosis study showed that the median disease-free survival （DFS）time in Uyghur group was 64.5 months,with 70 months in Han group,with 66 months in Luminal A,66 months in Luminal B,64 months in Erb-B2 Overexpres-sion,70 months in Basal-like.There were significant differences in DFS （P =0.004）and molecular sub-types （P =0.024）in two ethnic groups.Conclusion Molecular subtypes may be one of the prognostic fac-tors of Xinjiang Uyghur and Han patients with breast cancer.
出处
《新疆医科大学学报》
CAS
2014年第11期1447-1450,共4页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区科技支疆项目(201291172)
关键词
乳腺癌
分子分型
预后
民族
breast cancer
molecular subtype
prognosis
ethnicity
