摘要
目的探讨胸腔积液和血清中癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)和神经元特异性烯醇化酶(NSE)检测在肺癌的鉴别诊断和病理分型中的临床价值。方法将180例胸腔积液患者分为良性胸腔积液组(55例)和肺癌组(125例),分别对各组患者胸腔积液和血清中的CEA、NSE和CYFRA21-1水平进行检测,并对检测结果进行比对分析。结果肺癌组胸腔积液和血清中的CEA、NSE和CYFRA21-1水平均明显高于良性胸腔积液组(P<0.05)。肺癌组中,腺癌组胸腔积液和血清中的CEA水平明显高于良性胸腔积液组,同时高于鳞癌组和小细胞肺癌组,差异有统计学意义(P<0.05);鳞癌组胸腔积液和血清中的CYFRA21-1水平明显高于良性胸腔积液组,同时高于腺癌组和小细胞肺癌组,差异有统计学意义(P<0.01);小细胞肺癌组胸腔积液和血清中的NSE水平明显高于良性胸腔积液组,同时高于腺癌组和鳞癌组,差异有统计学意义(P<0.01)。CEA在腺癌组中的检测阳性率高于鳞癌组和小细胞肺癌组,差异有统计学意义(P<0.05);CYFRA21-1在鳞癌组中的检测阳性率高于腺癌组和小细胞肺癌组,差异有统计学意义(P<0.05);NSE在小细胞肺癌组中的阳性率高于鳞癌组和腺癌组,差异有统计学意义(P<0.01)。结论胸腔积液及血清中CEA、CYFRA21-1和NSE分别是腺癌、鳞癌和小细胞肺癌的较特异的肿瘤标志物,对肺癌的鉴别诊断和病理分型有一定的临床意义。
Objective To explore clinical value of detection of carcinoembryonic antigen（CEA） ,cytokeratin 19 fragment（CY-FRA21-1） and neuron specific enolization enzyme（NSE） in pleural effusion and serum during the differential diagnosis and patho-logical classification of lung cancer .Methods 180 patients with pleural effusion were divided into two groups ,one including 55 be-nign pleural effusion cases（benign pleural effusion group） and the other including 125 lung cancer cases（lung cancer group） .CEA , NSE and CYFRA21-1 in pleural effusion and serum of two groups were measured ,respectively ,and the measure results between two groups were conducted .Results CEA ,NSE and CYFRA21-1 levels in lung cancer group were significantly higher than those in benign pleural effusion group（P〈0 .05） .CEA levels in pleural effusion and serum in lung adenocarcinoma group were significantly higher than those in benign pleural effusion group ,lung squamous carcinoma group and small cell lung cancer group（P〈0 .05） .CY-FRA21-1 levels in pleural effusion and serum in lung squamous carcinoma group were significantly higher than those in benign pleu-ral effusion group ,lung adenocarcinoma group and small cell lung cancer group（P〈0 .01） .NSE levels in pleural effusion and serum in small cell lung cancer group were significantly higher than those in benign pleural effusion group ,lung adenocarcinoma group and lung squamous carcinoma group（P〈 0 .01） .The positive detection rate of CEA in lung adenocarcinoma group was significantly higher than that in lung squamous carcinoma group and small cell lung cancer group（P〈0 .05） .The positive detection rate of CY-FRA21-1 in lung squamous carcinoma group was significantly higher than that in lung adenocarcinoma group and small cell lung cancer group（P〈0 .05） .The positive detection rate of NSE in small cell lung cancer group was significantly higher than that in lung squamous carcinoma group and lung adenocarcinoma group（P〈0 .01） .Conclusion CEA ,CYFRA21-1 and NSE in pleural effusion and serum are specific tumor markers of lung adenocarcinoma ,lung squamous carcinoma and small cell lung cancer ,respectively , which may have a certain clinical significance for the differential diagnosis and pathological classification of lung cancer .
出处
《国际检验医学杂志》
CAS
2014年第19期2613-2615,共3页
International Journal of Laboratory Medicine
关键词
胸腔积液
肿瘤标志物
肺腺癌
肺鳞癌
小细胞肺癌
pleural effusion
tumor markers
lung adenocarcinoma
squamous cell lung carcinoma
small cell lung cancer
