摘要
目的通过研究冠状动脉粥样硬化性心脏病(冠心病)患者血浆氧化型低密度脂蛋白(oxidized low-density lipoprotein cholesterol,OX-LDL-C)和同型半胱氨酸(homocysteine,HCY)浓度与Gensini评分的相关性,探讨其对冠状动脉病变严重程度的预测价值。方法选择疑似冠心病患者86例,据冠状动脉造影结果分为冠心病组(67例)及对照组(19例),冠心病组根据Gensini评分分为轻度亚组(23例)、中度亚组(22例)和重度亚组(22例)。分析各组血浆OX-LDL-C和HCY浓度与Gensini评分的相关性。结果 (1)冠心病组与对照组血浆OX-LDL-C、HCY浓度比较,冠心病组较高,差异有统计学意义(P<0.05)。(2)Gensini评分三个亚组间血浆OX-LDL-C和HCY浓度比较,差异有统计学意义(P<0.05);随着冠状动脉狭窄程度加重,血浆OX-LDL-C、HCY浓度有增高趋势,差异有统计学意义(P<0.05)。(3)Gensini评分与血浆OX-LDL-C(r=0.805,P<0.01)、HCY(r=0.700,P<0.01)浓度呈正相关,且OX-LDL-C与Gensini评分相关性较HCY高;血浆OX-LDL-C与HCY浓度呈正相关(r=0.698,P<0.01)。结论血浆OX-LDL-C和HCY浓度与Gensini评分有关,血浆OX-LDL-C与HCY具有相关一致性,联合检测血浆OX-LDL-C和HCY浓度可更好地了解病情、指导治疗及判断预后。
Objectives To investigate the clinical significance of plasma concentrations of oxidized low-density lipoprotein cholesterol （OX-LDL-C） and homocysteine （HCY） in patients with coronary heart diseases （CHD）.Methods Totally 86 cases were divided into coronary heart disease group （n=67） and control group （n=19） according to the results of coronary angiographic examination.Patients in CHD group were further divided into mild subgroup （n=23）,moderate subgroup （n=22） and sever subgroup （n=22） according to Gensini score.Plasma concentrations of OX-LDL-C and HCY were measured and their correlations with coronary artery lesions were analyzed.Results （1） Plasma concentrations of OX-LDL-C and HCY were significantly higher in CHD group than those in control group （P〈0.05）.（2） Differences in plasma concentrations of OX-LDL-C and HCY of the three subgroups were obvious.They increased by the severity of coronary artery stenoses （P〈0.05）.（3） Plasma concentrations of OX-LDL-C （r=0.805,P〈0.01） and HCY （r=0.700,P〈0.01） were positively related with Gensini score in patients with CHD.A significant positive correlation was found between plasma concentrations of OX-LDL-C and HCY （r=0.698,P〈0.01）.Conclusions Plasma concentrations of OX-LDL-C and HCY are closely related to coronary atherosclerosis,which suggests that OX-LDL-C and HCY may be indicators to evaluate the severity of coronary artery stenoses.
出处
《岭南心血管病杂志》
2014年第5期587-590,共4页
South China Journal of Cardiovascular Diseases
基金
2011年佛山市医学科学技术研究计划项目(项目编号:2011092)
