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头痛宁治疗偏头痛效果及安全性的Meta分析 被引量:6

Meta analysis on curative effects and security of Toutongning Capsules in treatment of migraine
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摘要 目的评价头痛宁胶囊治疗偏头痛的临床效果。方法计算机检索维普、中国生物医学文献数据库、中国知网、万方数据库进行资料收集,筛选2001年1月1日~2014年6月1日间所有使用头痛宁与西药治疗偏头痛的随机对照试验(RCT),同时手动检测其参考文献。采用Jadad 7分评分法评价纳入文献质量,由2名评价者独立进行文献质量评价和资料提取后,采用RevMan 5.0软件进行Meta分析。结果检出符合标准RCT文献共144篇,筛选出10项研究(中药组602例,西药组566例)进行Meta分析。头痛宁治疗偏头痛效果与西药比较,其总OR=1.19,95%CI为(1.12,1.27);在治愈率方面,OR=1.61,其95%CI为(1.24,2.09);在安全性方面,其不良反应出现OR=1.64,95%CI为(0.29,0.90)。结论头痛宁治疗偏头痛效果确切,比西药单纯治疗效果好,两者合用可能取得更好的效果,但尚需更多高质量的研究以增加证据的强度。 Objective To review the curative effects of Toutongning Capsules on migraine. Methods The literature of randomized and controlled trials(RCT) about compared treatment of migraine with Toutongning Capsules and western medications were retrieved from Sinomed, VIP, CNKI and Wanfang from January 1, 2001 to June 1, 2014, and at the same time, the references were manually retrieved. Jadad 7 was used to evaluate the quality of included papers. After that, materials were extracted by 2 independent reviewers, all data was given Meta analysis by using RevMan 5.0 software. Results There were 144 papers retrieved and 10 RCTs included(experimental group of 602 cases, control group of 566 cases). Compared with western medications, Toutongning Capsules: in clinical curative effect, OR = 1.19, 95%CI was(1.12, 1.27); in the cure rate, OR = 1.61, 95%CI was(1.24, 2.09); in the adverse drug reaction, OR = 1.64, 95%CI was(0.29, 0.90). Conclusion Toutongning Capsules is a safe and effective Chinese patent medicine for treating migraine and its curative effect is better than that of western medications only, and the combination therapy may obtain a great benefit. High-quality trials are required to prove and review its effect further.
出处 《中国医药导报》 CAS 2014年第30期65-69,共5页 China Medical Herald
关键词 头痛宁 偏头痛 META分析 Toutongning Capsules Migraine Meta-analysis
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