摘要
目的观察四磨汤口服液对功能性消化不良(肝脾气滞证)的疗效及对血清中NO、AchE、CCK、SP的影响。方法将60例患者随机分为四磨汤加模拟多潘立酮治疗组30例和多潘立酮加模拟四磨汤对照组30例,治疗14 d,观察治疗前后总体疗效、症状总积分、单项症状改善情况及血清中NO、AchE、CCK、SP变化情况。结果经14 d治疗后,两组功能性消化不良患者的临床总有效率差异无统计学意义(P>0.05),而四磨汤在改善部分临床症状方面优于多潘立酮;四磨汤和多潘立酮均能降低功能性消化不良患者血清中NO、CCK的含量,提高功能性消化不良患者血清中AchE、SP的含量,从而调节功能性消化不良患者胃肠运动,且四磨汤对功能性消化不良患者胃肠激素的调节作用优于多潘立酮(P<0.01或P<0.05)。结论四磨汤治疗功能性消化不良疗效确切,对患者血清NO、AchE、CCK、SP含量的调节是其可能作用机制。
Objective： To evaluate the clinical efficacy of Siren decoction on functional dyspepsia with Qi stag- nancy of both liver and spleen and its effect on nitrie oxide, acetylcholinesterase, cholecystokinin and substance P in serum. Methods： 60 patients were randomly divided into Simo decoction plus Domperidone placebo group and Domperidone plus Simo decoction placebo group. 14 days after treatment,clinical symptoms,the levels of Nitrie Oxide, Acetylcholinesterase, Cholecystokinin and Substance P in serum were observed before and after treatment. Results： After 14 days＇ treatment, the total effective rates of both groups had no statistically significant difference （P〉0.05） ,and the two had significant difference （P〈0.05）. On improving clinical symptoms,Simo decoction is better than domperidone. Both Siren decoction and domperidone could reduce the contents of NO and CCK in FD patients＇ serum,increase the contents of AchE and SP in serum, thus regulate the gastrointestinal motility. And the regulative effect of Simo decoction on gastrointestinal motility was better than that of domperidone, and two groups had significant difference （P〈 0.05 or P〈 0.01 ）. Conclusion： Simo decoction has good effect treating functional dyspepsia,which may be related to its regulative effect on the contents of NO,AchE,CCK and SP.
出处
《中国中医急症》
2014年第10期1791-1792,1833,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
国家重点基础研究计划课题(No.2009CB523002)
关键词
功能性消化不良
肝脾气滞证
四磨汤口服液
疗效
胃肠激素
Functional dyspepsia
Qi stagnancy of liver and spleen
Simo decoction
Clinical efficacy
Gastroin-testinal hormone
