摘要
目的研究孕妇妊娠早期碘营养及对甲状腺功能的影响。方法以广州市新海医院产科门诊的1126例妊娠早期孕妇作为研究对象,收集其空腹晨尿及静脉血,促甲状腺激素及游离甲状腺素采用常规电化学发光法,尿碘监测采用国家标准《尿中碘的砷铈催化分光光度测定方法》测定尿标本中碘含量。结果 1126例孕妇甲亢患病率为3.1%,亚甲亢患病率为4.8%,甲减患病率为2.9%,亚甲减患病率为5.9%,低甲状腺素血症患病率为2.8%,尿碘中位数为145.12μg/L,患有与不患有甲状腺疾病的孕妇TPOAb(23.3%和16.3%),其阳性率差异无统计学意义(P>0.05)。尿碘中位数与促甲状腺激素相关系数为-0.098。结论孕妇妊娠早期碘营养水平异常直接影响到母体及胎儿的甲状腺功能,掌握孕妇早期碘营养水平,定期监测尿碘及甲状腺功能对于合理摄入碘、母体甲亢的控制、妊娠的顺利及胎儿的发育至关重要。
Objective To study the effect on iodine nutrition and thyroid function of pregnant women during early preg- nancy. Methods 1126 cases of women who were in our hospital obstetric clinic for routine prenatal care during early pregnancy were set as research subjects, Electrochemiluminescence method was used for the determination of thyroid stim- ulating hormone （TSH） and free thyroxine in blood specimens. Fasting morning urine and serum samples were collected. Utilize arsenic cerium catalytic spectrophotomemc determination of iodine content in urine specimens was conducted. Re- suits In our hospital, 1126 cases of early pregnancy women, the prevalence of hyperthyroidism, subclinical hyperthyroid- ism, subclinical hypothyroidism, hypothyroidism was 3.1% ,4.8 %, 2.9% ,5.9% and 2.8% , respectively. The median of urinary iodine was 145.12 ~g/L. Prevalence of thyroid dysfunction was higher in TPOAb-positive individuals（23.3% vs. 16.3 %, P 〉 0.05 ）. Correlation coefficient of median urinary iodine concentration and TSH was - 0.098. Conclusion The level of abnormal iodine nutrition directly affected the thyroid function in mother and fetus. It was recommended to grasp the level of iodine nutrition, regular monitoring of urinary iodine and thyroid function in early pregnant women. It was important to reasonable intake iodine, control of maternal hyperthyroidism, the development of pregnancy and fetal is smooth.
出处
《中华全科医学》
2014年第12期1968-1969,2050,共3页
Chinese Journal of General Practice
基金
广东省卫生厅资助项目(WSTJJ20121204)
关键词
妊娠早期
碘营养
甲状腺功能
Early pregnancy
Iodine nutrition
Thyroid function
