摘要
目的探讨感染后咳嗽的气道炎症动态变化。方法将67例感染后咳嗽患者随机分为中药组34例和对照组33例,分别给予中药配方颗粒(风寒方)和安慰剂口服。两组均治疗10 d,随访7 d。随访后根据咳嗽症状评分评价临床缓解率,咳嗽缓解时间和咳嗽复发情况。治疗前后进行诱导痰检测,并用ELISA方法检测痰上清中P物质(SP)、白介素8(IL-8)、分泌型免疫球蛋白(sIgA)的水平。结果中药组缓解率为97.1%,与对照组93.9%缓解率相比,无显著差异(P>0.05)。中药组痰中性粒细胞比例治疗后比治疗前显著降低(66.7±21.9%vs.54.8±17.5%,P<0.05),同时痰上清中IL-8和SP的浓度在治疗后显著下降(377.7±234.3 pg/ml vs.273.5±225.2 pg/ml,P<0.01;665.4±229.0 pg/ml vs.562.0±244.7 pg/ml,P<0.05),而sIgA水平在治疗后显著上升(444.7±201.3 ng/ml vs.565.2±192.6ng/ml,P<0.01);对照组的炎症细胞比例以及炎症介质IL-8和SP水平在治疗前后的差异均无统计学意义(P>0.05)。结论感染后咳嗽存在显著的气道炎症,采用中药配方(风寒方)治疗可改善气道炎症,但对病情控制无显著作用。
Objective To investigate the change of airway inflammation in postinfectious cough.Methods A total of 67 patients with postinfectious cough were enrolled,Chinese medicine （34 cases） and control group（33 cases）,and administered with Chinese medicine （Fenghan recipe） or placebo for 10 days,and followed up for 7days after treatment.The clinical remission rate,remission duration at the end of the study and recurrence of cough during follow up were evaluated.The induced-sputum test for differential cell was performed before and after treatment,and the level of substance P （SP）,interleukin-8 （IL-8）,secretory immunoglobulin A（sIgA） in the supernatant of sputum were measured by ELISA.Results There was not significant difference in remission rate between Chinese medicine group and control group （97.1％ vs.93.9％,P ＞ 0.05）.The sputum neutrophil count was decreased in Chinese medicine group after the treatment（66.7 ± 21.9％ vs.54.8 ± 17.5％,P ＜0.05）.Significant decrease was shown for IL8,SP level（377.7 ±234.3 pg/ mlvs.273.5 ±225.2 pg/ml,P＜0.01; 665.4 ±229.0 pg/ml vs.562.0 ±244.7 pg/ml,P＜0.05）,increase for sIgA（444.7 ±201.3 ng/ml vs.565.2 ± 192.6 ng/ml,P ＜0.01） after treatment with Chinese medicine.No significant changes of differential cell count and level of inflammatory mediators were found after treatment in control group.Conclusions Obvious airway inflammation exists in patients with postinfectous cough,which can be inhibited by Chinese medicine （Fenghan Recipe） without significant effect on symptoms control.
出处
《中华肺部疾病杂志（电子版）》
CAS
2014年第5期13-17,共5页
Chinese Journal of Lung Diseases(Electronic Edition)
基金
"十一五"国家科技支撑计划资助项目(2007BAI20B086)
关键词
感染后咳嗽
发病机制
神经源性炎症
Postinfectious cough
Pathogenesis
Neurogenic inflammation
