摘要
目的观察全真一气汤多糖对慢性心功能不全模型大鼠心功能、血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)的影响。方法应用尾静脉注射阿霉素的方法建立心衰大鼠模型,随机分为模型组、卡托普利组、全真一气汤多糖低、中、高剂量组,并设立空白对照组。分别给药卡托普利2.25 mg/kg;全真一气汤多糖0.3,0.9,2.7 g/kg,空白对照组和模型组给予等体积的蒸馏水,灌胃,1次/d,共4周。观察全真一气汤多糖对模型大鼠心功能,AngⅡ和ALD的影响。结果模型组的LVEDV值(0.60±0.043)mL最高,多糖低、中、高剂量组与模型组比较,差异具有统计学意义(P<0.01);模型组LVEF值(62.25±3.37)%最低,多糖低、中、高剂量组与模型组比较,差异具有统计学意义(P<0.05或P<0.01);模型组的AngⅡ,ALD水平[(2410.35±96.73)ng/mL,(326.38±12.92)ng/mL]最高,与多糖各剂量组比较差别均有统计学意义(P<0.01)。结论全真一气汤多糖可以改善心衰模型大鼠心功能,降低心衰模型大鼠血清的AngⅡ、ALD水平。
Objective To observe the effects of Polysaccharide of Quanzhen Yiqi Decoction on cardiac function,AngⅡ and ALD of model rats with chronic heart failure.Methods Heart failure animal model was established by the method of intravenous injection of adriamycin from tail,and were randomly divided into model group,Captopril group,Polysaccharide of Quanzhen Yiqi Decoction low-dose,middle-dose,high-dose group.Blank control group was also established.Each group was given 2.25 mg of Captopril.kg and 0.3,0.9,2.7 g /kg of Polysaccharide of Quanzhen Yiqi Decoctions,and the blank control group and model group were given the equal volume of distilled water for intragastric administration once a day for a total of4 weeks.Effects of Polysaccharide of Quanzhen Yiqi Decoction on cardiac function,AngⅡ and ALD of model rats were observed.Results LVEDV value（0.60 ±0.043） mL of the model group was the highest compared with that in Polysaccharide of Quanzhen Yiqi Decoction low-dose,middle-dose,high-dose group,the differences among them were statistically significant（P〈0.05）.LVEF value（62.25 ±3.37 %） of the model group was the lowest compared with that in Polysaccharide of Quanzhen Yiqi Decoction low-dose,middle-dose,high-dose group,the differences among them were statistically significant（P〈0.05 or P〈0.01）.Level of AngⅡ and ALD [（2410.35 ± 96.73） ng /mL,（326.38 ± 12.92） ng /mL]were the highest compared with that in Polysaccharide of Quanzhen Yiqi Decoction low-dose,middle-dose,high-dose group,the differences among them were statistically significant（P〈0.01）.Conclusion Quanzhen Yiqi Decoction can improve cardiac function,reduce serum AngⅡ and ALD levels of model rats with heart failure.
出处
《吉林中医药》
2014年第10期1000-1002,共3页
Jilin Journal of Chinese Medicine
基金
广东省自然科学基金项目:全真一气汤多糖对慢性心功能不全大鼠心室重构的影响(S2011040003766)
