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老年胃癌围术期血清IL-2CEA和CA72-4水平测定的临床意义 被引量:2

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摘要 目的探讨血清白细胞介素2(IL-2)、癌胚抗原(CEA)、糖类抗原72-4(CA72-4)的水平在老年胃癌患者围手术期中的意义。方法选取2011年5月~2014年2月在外科行手术治疗的老年胃癌患者42例,其中男25例,女17例,年龄62~76岁,平均(65.4±6.3)岁,分别采用免疫放射分析法和电化学发光免疫分析法检测手术前后不同时期血清CEA、IL-2和CA72-4水平,并与同期35例健康体检者进行比较。结果胃癌患者血清IL-2、CEA、CA72-4的水平均显著高于健康对照组,差异有统计学意义(分别为P〈0.01、P〈0.05、P〈0.01);CEA阳性组的IL-2阳性率明显高于CEA阴性组,分别为78.57%和19.23%,差异有统计学意义(P〈0.01);CA72-4阳性组的IL-2阳性率明显高于CA72-4阴性组,分别为81.25%和12.50%,差异有统计学意义。胃癌患者术前血清IL-2水平低于健康对照组,而血清CEA和CA72-4水平均高于健康对照组,差异均有统计学意义(P均〈0.05);IL-2术后水平逐渐升高,术后6月时接近健康对照组水平(P〉0.05);CEA和CA72-4水平术后逐渐降低,术后6月接近健康对照组水平,差异无统计学意义(P〉0.05)。结论 IL-2可以与CEA、CA72-4作为有效的肿瘤标志物,在胃癌的诊治和预后判断等方面具有一定的临床应用价值。
出处 《内蒙古医学杂志》 2014年第8期970-972,共3页 Inner Mongolia Medical Journal
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