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美罗华联合CHOP方案治疗B细胞性非霍奇金淋巴瘤效果观察 被引量:10

Study on the effect of rituximab combined with CHOP regimen in the treatment of B cells non Hodgkin's lymphoma
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摘要 目的探讨美罗华联合CHOP方案治疗B细胞性非霍奇金淋巴瘤的临床效果及不良反应。方法选择B细胞性非霍奇金淋巴瘤60例随机分成观察组和对照组各30例。观察组采用美罗华联合CHOP方案治疗,对照组仅采用CHOP方案治疗,比较两组临床疗效及不良反应情况。结果观察组患者临床疗效明显优于对照组(P<0.05);不良反应除发热例数多于对照组外(P<0.05),其余两组比较差异无统计学意义(P>0.05)。结论对B细胞性非霍奇金淋巴瘤患者采用美罗华联合CHOP方案治疗,能够有效提高患者的临床疗效,值得临床推广。 Objective To explore the therapeutic effect and adverse reaction of rituximab combined with CHOP regimen in the treatment of B cell non Hodgkin′s lymphoma.Methods Sixty patients with B cell non Hodgkin′s lymphoma were randomly divided into observation group(n=30) and control group(n=30).The observation group were treated with rituximab combined with CHOP regimen, the patients in control group only received CHOP treatment.The clinical therapeatic effect and adverse reaction between two groups were compared.Results The clinical therapeatic effect in the observation group were significantly higher than that in control group,the difference was statistically significant(P〈0.05).Conclusion Rituximab combined with CHOP in the treatment of B cells non Hodgkin lymphoma can effectively improve the treatment efficiency,and is worth clinical promotion.
作者 武春莲
出处 《中国临床新医学》 2014年第10期944-946,共3页 CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词 B细胞性非霍奇金淋巴瘤 美罗华 CHOP方案 B cell non Hodgkin's lymphoma Rituximab CHOP regimen
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  • 1夏忠军,王风华,黄慧强,骆卉妍,李宇红,林桐榆,姜文奇,管忠震.含美罗华方案治疗B细胞性惰性淋巴瘤34例报告[J].癌症,2006,25(4):490-494. 被引量:9
  • 2Swain SM,Whaley FS,Ewer MS.Gongestive heart failure in patients treated with doxorubicin:a retrospective analysis of three trials[J].Gancer,2003,97:2869-2879.
  • 3Feuqier P,van Hoof A,Sebban G,etal.Long-term results of the R-CHOP study of elderly patients with diffuse large B-cell lymphoma:A study by the Group Etude des lymphoma de LAdute.J Glin Oncol,2005,18(23):4117-4126.
  • 4VOSE JM,LINK BK,GROSS BARD ML et al.Prase Ilsmdy of rituximab in combination with CHOP chemotherapy in patients with previously untreated,aggressive non-Hodgkin's lymphoma.J Clin Oncol,2001,19(2):389-397.
  • 5牛伶.基因药物'美罗华'治疗淋巴瘤安全有效.国内新药信息,2000,6.
  • 6Michallet AS,Coiffier B.Recent developments in the treatment of aggressive non-Hodgkin lymphoma[J].Blood Rev,2009,23(1):11-23.
  • 7Sonet A,Bosly A.Rituximab and chemotherapy in diffuse large B- cell lymphoma[J].Expert Rev Anticancer Ther,2009,9(6):719-726.
  • 8Tucci A,Ferrari S,Bottelli C,et al.A comprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy[J].Cancer,2009,115(19):4547-4553.
  • 9Grillo Lopez AJ,Cheson BD,Homing SJ,et al.Response criteria for NHL:important of 'nomal' lymphnode size and correlations with response rates[J].Ann Oncol,2000,11:399 - 408.
  • 10Mclaughlin P,Grillo-Lo peza J,Link BK,et al.Rituxmab chimeric anti-CD20 monoclonal anti-body therapy for elapsed indolent lymphoma haft of patients 2 spond to a four dose treatment program[J].J Clin Oneo1,1998,16:2825- 2833.

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  • 1薛晓弘,刘杰.美罗华联合CHOP方案治疗B细胞性非霍奇金淋巴瘤的临床观察[J].基层医学论坛,2013,17(S1):29-30. 被引量:5
  • 2国家中医药管理局.中华人民共和国医药行业标准.中医病症诊断疗效标准[M].南京:南京中医药大学出版社,1994.201-203.
  • 3Kitahara H.Brentuximab vedotin(replased/refractory Hodgkin lymphoma and CD30positive non-Hodgkin lymphoma.Gan To Kagaku Ryoho,2015;42(5):550~552.
  • 4Khurana A,Kaur P,Chauhan AK,et al.Primary Non Hodgkin's Lymphoma of Left Adrenal Gland-A Rare Presentation.J Clin Diagn Res,2015;9(4)∶XD01~XD03.
  • 5Nedelcu RE,Kiss E,Ciorba M,et al.Mediastinal fibrosis and Hodgkin lymphoma mimicking bronchiolitis obliterans organizing pneumonia.Pneumologia,2015;64(1)∶40~45.
  • 6De Roos AJ,Martínez~Maza O,Jerome KR,et al.Investigation of epstein~barr virus as a potential cause of B~cell non~Hodgkin lymphoma in a prospective cohort.Cancer Epidemiol Biomarkers Prev,2013;22(10)∶1747~1755.
  • 7Cheson BD, Homing SJ, Coiffier B,et al.Report of an in- ternational workshop to standardize response criteria for non-Hodgkin's lymphomas [ J].J Clin Oncol, 1999, 17 (4) : 1244-1253.
  • 8Pasqualucci L,Dalla-Favera R.The Genetic Landscape of Diffuse Large B-Cell Lymphoma [ J ]. Semin Hematol, 2015,52(2) :67-76.
  • 9Ha H, Keam B, Kim TM, et al. Reduced dose intensities of doxorubicin in elderly patients with DLBCL in rituximab era [ J ]. Cancer Res Treat, 2015, 10 ( 41 ) : 339-342.
  • 10Tsai PC, Hernandez-Ilizaliturri FJ, Bangia N, et al. Regu- lation of CD20 in rituximab-resistant cell lines and b-cell non-hodgkin tymphoma [ J ]. Clin Cancer Res, 2012, 18 (4) : 1039-1050.

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