摘要
研究不同水温对氟苯尼考在中华绒螯蟹血淋巴、肌肉和肝脏组织中的代谢规律和组织分布的影响。在17℃和28℃水温下,以20 mg/kg剂量单次肌肉注射给药,于给药后不同时间点取各组织样品,氟苯尼考药物含量由高效液相色谱法测定。研究结果表明在两个温度下,血淋巴和肌肉组织中氟苯尼考含量瞬时达到峰值,而肝脏中氟苯尼考含量则随给药时间,呈先上升后下降的趋势。氟苯尼考在中华绒螯蟹体内代谢规律符合二室开放模型,吸收半衰期、消除半衰期、药时曲线下总面积均与温度呈负相关,而总体清除率与温度呈正相关。
A pharmacokinetic study of florfenicol following a single intramuscular administration（20 mg /kg）was carried out in the Chinese mitten- handed crab at 17 and 28℃ water temperature.Hemolymph,muscle and liver samples were collected at different time after injection.The tissue level of flofenicol was determined by high- performance liquid chromatography method.The florfenicol level in hemolymph and muscle reached maximum momentarily,while that in liver increased firstly and reduced at last with administration time.The pharmacokinetics of florfenicol in the Chinese mitten- handed crab was conformed to a two- compartment model.At 17 and 28℃,the absorption half- life,elimination half- life and the area under the concentration- time curve from zero to infinity of florfenicol in liver were found to have a negative correlation with temperature,whereas total body clearance revealed a positive correlation.
出处
《福建水产》
2014年第5期359-365,共7页
Journal of Fujian Fisheries
基金
江苏省农业科技自主创新[CX(13)3095]
关键词
中华绒螯蟹
氟苯尼考
代谢动力学
温度
Eriocheir sinensis
florfenicol
pharmacokinetics
temperature
