摘要
辅助性T细胞17(Thl7)是近年来发现的一群以表达IL-17而命名的新型CD4+T细胞亚群,可分泌IL-17A、IL-17F、IL-21、IL-22、IL-26等多种细胞因子。TGF-β、IL-6、IL-21、IL-23等在Th17细胞分化过程中起着积极的促进作用,而IL-27、IL-2、IFN-γ等则参与Th17细胞分化发育的负向调控。Th17细胞具有促进免疫反应的效应,在以慢性炎症为损伤机制的自身免疫性疾病中发挥着重要作用。越来越多的研究发现Th17细胞与再生障碍性贫血(AA)的发生发展密切相关,并有望成为AA诊断、治疗、预后及预防的一个新靶点。
During the past few years,a novel family of CD4 ＋ T cell lineage was detected and named as Th17 cells because of its unique ability expressing IL-17,which also can produce IL-17A,IL-17F,IL-21,IL-22 and IL-26.Some cytokines,such as TGF-β,IL-6,L-23 may promote the differentiation of Th17 subset,whereas some cytokines,such as IL-21,IL-2,IFN-γ,may have inhibitory effects.Th17 cells serving as immune effectors play an important role in autoimmune diseases caused by chronic inflammation injury.More and more studies confirmed that Th17 cells have closely correlations with the development of aplastic anemia,and may be a new target in the diagnosis,therapy,prognosis and prophylaxis of aplastic anemia.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2014年第5期1463-1466,共4页
Journal of Experimental Hematology
