摘要
胃原发性恶性黑色素瘤是一种罕见的高度恶性肿瘤,应该与转移性胃恶性黑色素瘤、胃低分化腺癌、胃其他原发性肿瘤及转移瘤等相鉴别。该肿瘤位于胃底部,呈浸润性生长。镜下可见肿瘤细胞弥漫性片状分布,细胞呈多形性,细胞核呈空泡状,核仁明显,核分裂象易见,肿瘤细胞内见少量黑色素颗粒。免疫组织学检查发现肿瘤细胞中HMB45、S-100蛋白呈强阳性表达,而不表达Cytokeratin、EMA、CEA。我们通过对1例胃原发性恶性黑色素瘤患者的报道并文献复习,提高对该病的认识。
Primary malignant melanoma at the gastric is extremely rare.It should be differentiated from the other gastric tumors,including metastatic gastric malignant melanoma,other primary tumors and metastatic tumors in the gastric.Under the microscope,tumor cells distribute diffuse patchy,pleomorphic,the nuclear vacuolization,the nucleoli prominent,mitotic easy to see,and a small amount of melanin granules in the tumor cells.Immunohistochemical staining for HMB-45 and S-100 is positive,and negative for cytokeratin,EMA and CEA in the tumor cells.We reported a patient with primary malignant melanoma of stomach and reviewed literatures to know it better.
出处
《胃肠病学和肝病学杂志》
CAS
2014年第10期1243-1244,共2页
Chinese Journal of Gastroenterology and Hepatology
关键词
胃肿瘤
恶性黑色素瘤
免疫组织化学
Gastric neoplasms
Malignant melanoma
Immunohistochemistry
