摘要
目的 了解本院狼疮肾炎（LN）患者高尿酸血症的患病率及其相关危险因素.方法 回顾性分析1998年1月至2010年12月于中山大学附属第一医院确诊为LN的959例患者的临床及病理特征.采用多因素Logistic回归分析LN患者高尿酸血症发生的影响因素.结果 本研究LN患者中,高尿酸血症的患病率为57.7％,其中CKD1～5期各期患者高尿酸血症的患病率分别为44.1％、65.7％、74.7％、77.6％、73.9％.LN患者伴发高尿酸血症的独立危险因素为血三酰甘油水平的升高及内皮细胞增生（≥50％）;肾损害早期（CKD1～2期）LN患者伴发高尿酸血症的独立危险因素为血三酰甘油水平升高;肾损害中晚期（CKD3～5期）LN患者伴发高尿酸血症的独立危险因素为dsDNA阳性及抗心磷脂抗体IgM阳性.结论 本研究中LN患者高尿酸血症的患病率为57.7％,LN患者包括肾损害早期患者高尿酸血症发生与血三酰甘油密切相关,提示LN患者高尿酸血症的发生与代谢紊乱密切相关.
Objective To investigate the prevalence and related risk factors of hyperuricemia in patients with lupus nephritis （LN） in Southern China.Methods A single center retrospective study,959 adult LN patients diagnosed with biopsy-proven,who admitted to The First Affiliated Hospital,Sun Yat-sen University from 1998.01 to 2010.12 were recruited.Results Among this cohort,the prevalence of hyperuricemia was 57.7％.The prevalence of hyperuricemia for CKD stage 1,2,3,4,5 was 44.1％,65.7％,74.7％,77.6％,73.9％,respectively.Logistic regression analysis showed that increased serum triglyceride level and endothelial proliferation （≥50％） were independent risk factors of hyperuricemia in LN patients; Also,increased serum triglyceride level was an independent risk factor of hyperuricemia in LN patients of CKD stage 1-2; Positive dsDNA and positive anticardiolipin antibody were independent risk factors of hyperuricemia in LN patients of CKD stage 3-5.Conclusion The prevalence of hyperuricemia in LN patients from this cohort is 57.7％.Increased level of serum triglyceride is an independent risk factor associated with hyperuricemia in both overall LN patients and those of CKD stages 1-2.Therefore,the present study indicates that metabolic factors may influence each other,and should be paid more attention in the clinical practice of LN care.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2014年第11期805-812,共8页
Chinese Journal of Nephrology
基金
“十二五”国家科技支撑计划（2011BAI10B05）
中山大学5010项目（2007007）
