摘要
Elafin是一种内源性的低分子量丝氨酸蛋白酶抑制剂,它来自于其前体trappin-2（或称pre-Elafin）的蛋白水解.Elafin的N端区段可以在转谷酰胺酶的介导下与细胞外基质铰连,而C端可以继续发挥抗蛋白酶作用.此外,Elafin还有抗感染、抗炎和免疫调节作用.因此,在气道炎症性疾病的治疗方面,Elafin是一种极具吸引力的候选分子.
Elafin is an endogeneous low molecular weight inhibitor of serine proteases.It is derived from a precursor,trappin-2 or pre-Elafin by proteolysis.Elafin has a unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase,while retaining its inhibitory activity.Elafin has many biological functions as diverse as anti-bacterial,anti-fungal,anti-viral,anti-inflammatory,and immuno-modulatory functions,in addition to its inhibitory activity.Hence,Elafin has become an attractive candidate as therapeutic molecule in inflammatory lung disease.
出处
《国际呼吸杂志》
2014年第20期1576-1579,共4页
International Journal of Respiration
基金
国家自然科学基金（31171346）
