摘要
目的观察非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者血清炎症细胞因子水平与氧化应激参数的变化。方法检测182例新诊断的NAFLD患者和50例健康个体的血清TNF-α、IL-6、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)及相关生化指标,肝/脾CT比值,用稳态模型评估胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)。结果与健康对照组比较,NAFLD患者血清TNF-α、IL-6、MDA、餐后2 h血糖(2 h postprandial blood glucose,2hBG)、空腹胰岛素(fasting insulin,FINS)、餐后2 h胰岛素(2hINS)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、尿酸(UA)、游离脂肪酸(FFA)、超敏C反应蛋白(hsCRP)、丙氨酸转氨酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)以及体质量指数(BMI)、HOMA-IR均明显升高(均P<0.05),而血清SOD和肝/脾CT比值明显降低(均P<0.01)。NAFLD组患者血清TNF-α和IL-6水平均与HOMA-IR、FFA、TG、BMI、2hINS呈正相关(P<0.05),而血清MDA水平与ALT、AST呈正相关(P<0.01),血清SOD水平则与ALT呈负相关(P<0.01)。结论 NAFLD患者的炎症细胞因子水平与氧化应激参数明显升高,合并更多的代谢指标异常。
Objective To investigate the changes of inflammatory cytokines and oxidative stress- related parameters in patients with nonalcoholic fatty liver disease （NAFLD）. Methods One hundred and eighty-two newly-diagnosed NAFLD patients and 50 healthy subjects （control group ） were enrolled in the study. Serum tumor necrosis factor-ix （TNF-α）, intedeukin-6 （IL-6）,malondialdehyde （ MDA）, superoxide dismutase （SOD） and other relative biochemical indicators were measured. CT value ratio （liver and spleen） and homeostasis model assessment of insulin resistance （HOMA-IR） were also determined. Results Levels of serum TNF-α, IL-6, MDA, 2-h postprandial blood glucose （2hBG）, fasting insulin （ FINS）, 2-h postprandial insulin （ 2hlNS）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, triacylglyceride （TG）, uric acid （UA）, free fatty acids （FFA）, high sensitive C-reactive protein （hsCRP）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, gamma-glutamyl transferase （GGT）, body mass index （BMI）and HOMA-IR were significantly higher, SOD and CT value ratio （liver and spleen）were significantly lower in NAFLD group than those in control group （ P 〈 0.05 ）. In the NAFLD patients, TNF-α and IL- 6 were positively correlated with HOMA-IR, FFA, TG, BMI and 2hlNS （ P 〈 0.05 ）, MDA was positively correlated with ALT and AST （ P 〈 0.01 ）, SOD was negatively correlated with ALT （ P 〈 0.01 ）. Conclusion There are higher levels of inflammatory cytokines and oxidative stress-related parameters and more abnormal metabolic indexes in NAFLD patients than those in healthy individuals.
出处
《同济大学学报（医学版）》
CAS
2014年第4期71-75,共5页
Journal of Tongji University(Medical Science)
基金
上海市卫生局科课题(2009238)
关键词
非酒精性脂肪性肝病
炎症细胞因子
氧化应激参数
代谢综合征
nonalcoholic fatty liver disease
inflammatory cytokine
oxidative stress-relatedparameter
metabolic syndrome
