摘要
背景:有研究将纳米羟基磷灰石复合聚酰胺66材料用在早期股骨头坏死的治疗中取得了很好的疗效,可显著降低疼痛、延缓股骨头塌陷。目的:比较髓芯减压植骨合并纳米羟基磷灰石/聚酰胺66复合生物支架的置入、髓芯减压植骨合并钽棒置入治疗早期股骨头缺血性坏死的临床效果。方法:将60例早期股骨头坏死患者随机分入观察组和对照组,观察组采用髓芯减压植骨合并纳米羟基磷灰石/聚酰胺66生物支架置入治疗,对照组采用髓芯减压植骨合并钽棒置入治疗。比较两组手术时间、术后引流量、住院天数、住院费用、术后疼痛发生情况;随访12个月,比较两组Harris评分、影像学疗效评判情况和综合疗效。结果与结论:观察组术后引流量、住院时间、住院费用低于对照组(P<0.05),两组手术时间、术后发生疼痛例数比较差异无显著性意义(P>0.05)。Harris评分中,观察组仅行走辅助评分明显优于对照组(P<0.05),两组影像学疗效评判情况、综合疗效评判比较差异无显著性意义(P>0.05)。结果表明对于早期股骨头坏死患者,髓芯减压植骨合并钽棒置入和髓芯减压植骨合并纳米羟基磷灰石/聚酰胺66置入在改善患者临床症状方面疗效相当。
BACKGROUND：Nano-hydroxyapatite/polyamide 66 has been used in the treatment of early avascular necrosis and obtained the good curative effect that can significantly reduce the pain and delay the col apse of the femoral head. OBJECTIVE：To evaluate the efficacy of core decompression with bone graft and nano-hydroxyapatite/polyamide 66 scaffold implantation versus core decompression with bone graft and tantalum rod implantation in treating early-stage avascular necrosis of the femoral head. METHODS：Total y 60 patients with early femoral head necrosis were randomly divided into two groups：observation group and control group. The observation group was treated by core decompression with bone graft and nano-hydroxyapatite/polyamide 66 scaffold implantation, and the control group treated by core decompression with bone graft and tantalum rod implantation. Then, we compared the time of operation, postoperative drainage volume, hospital stay, hospitalization expense, the number of postoperative pain between two groups. Al the subjects were fol owed for 12 months. The efficacy of two different surgical methods was evaluated by Harris scores, imaging curative effect and comprehensive curative effect. RESULTS AND CONCLUSION：Postoperative drainage volume, hospital stay, and hospital expenses were lower in the observation group than the control group （P〈0.05）. There were no significant differences in the operation time and the number of postoperative pain between the two groups （P〉0.05）. In the Harris hip scoring, only walking auxiliary score in the observation group was significantly better than that in the control group （P〈0.05）. There were no significant differences in the X-ray change and comprehensive efficacy evaluation between the two groups （P〉0.05）. For patients with early osteonecrosis of the femoral head, core decompression with bone graft and tantalum rod or hydroxyapatitescaffold implantation have similar clinical efficacy.
出处
《中国组织工程研究》
CAS
CSCD
2014年第39期6292-6297,共6页
Chinese Journal of Tissue Engineering Research
