摘要
目的:研究龙蔓藤茶调节血脂的作用。方法:用高脂饲料喂养雄性SD大鼠,随机分为模型组、龙蔓藤茶高剂量组37.80 g·kg-1、中剂量组12.60 g·kg-1、低剂量组6.30 g·kg-1及降脂药物组(180 mg·kg-1),连续给药30 d,观察各组大鼠体质量、血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)等指标的变化。结果:各给药组体质量增长与模型组比较,差异无统计学意义(P>0.05),大鼠未出现明显中毒症状;模型组实验后的TC和TG明显高于实验前(P<0.05);给药30 d后,与模型组比较,龙蔓藤茶37.80 g·kg-1剂量组可显著降低高脂饲料大鼠血清TC和TG水平(P<0.05)。结论:龙蔓藤茶具有辅助降血脂的作用。
Objective：To study the effect of Longman Ampelopsis grossedentata on the level of serum lipid. Methods：The exper-imental rats were given high-fat diet during the experiment. The rats were randomly divided into the model group, high dose group （37. 80 g·kg^-1）, medium dose group （12. 60 g·kg^-1）, low dose group （6. 30 g·kg^-1） and lipid-lowering drug group （180 mg· kg^-1 ） . All the groups were administrated continuously for 30 days, and the effect on body weight, serum TC, TG and HDL-C were measured. Results：Compared with that of the model group, the increase of body weight in the other groups was not significant （ P〉0. 05）, and all the rats had no obvious poisoning symptom. TC and TG were higher after the high-fat diet administration than those be-fore the experiment in the model group, and the differences were statistically significant （P〈0. 05）. After the 30-day treatment, the levels of TC and TG in the high-dose group were significantly decreased compared with those of the model group （P〈0. 05）. Conclu-sion：Longman Ampelopsis grossedentata shows assistant therapeutic effect on serum lipid.
出处
《中国药师》
CAS
2014年第10期1631-1633,共3页
China Pharmacist
关键词
龙蔓藤茶
体质量
血脂
Longman Ampelopsis grossedentata
Body weight
Serum lipid
