摘要
目的探讨腹腔镜辅助直肠癌根治术在手术时间控制下对患者免疫功能的影响。方法 30例进展期直肠癌患者随机均分为腹腔镜组和开腹组,分别行腹腔镜辅助直肠癌根治术和常规开腹直肠癌根治术,分析两组手术前后血清自然杀伤细胞(NK)、CD3+、CD4+、CD8+、CD4+/CD8+比例的变化。结果两组患者术后CD3+、CD4+和CD4+/CD8+比例均较术前明显降低(P<0.05)。术后第5天,除CD4+/CD8+及NK细胞比例外,腹腔镜组与开腹组其他指标均有不同程度回升,但腹腔镜组恢复程度要优于开腹组(P<0.05);术后CD4+/CD8+比例虽然两组均持续下降,但腹腔镜组下降程度要弱于开腹组。术后第1、5天,两组NK细胞均无明显差异(P>0.05)。结论与常规开腹手术比较,腹腔镜辅助直肠癌根治术创伤小,对患者术后免疫功能影响较少。
Objective To explore the changes of immune function in the patients underwent laparoscope-assisted radical rectectomy.Methods Thirty patients with advanced rectal cancer received radical rectectomy by laparoscope-assisted surgery（group A,15cases）or conventional open abdominal operation（group B,15cases）.The changes of serum levels of natural killer cells（NK）,CD3＋,CD4＋,CD8＋and CD4＋/CD8＋ratio were analyzed on the day before and the 1st and 5th day after surgery.Results Serum levels of CD3＋,CD4＋,CD8＋and CD4＋/CD8＋ratio were lower after operation than those before in both groups（P〈0.05）.Serum levels of CD3＋,CD4＋and CD8＋began to recover on the 5th day after surgery,which were more in group A than those in group B（P〈0.05）.The CD4＋/CD8＋ratio was decreased continuously after surgery in both groups,which was less in group A than that in group B.On the 1st and 5th day after surgery,the percentages of NK cells were not significantly different between two groups（P〉0.05）.Conclusion Compared to conventional open abdominal operation,radical rectectomy by laparoscope-assisted surgery has the advantages of less injury and effect on immune function.
出处
《江苏医药》
CAS
北大核心
2014年第21期2575-2577,共3页
Jiangsu Medical Journal
关键词
直肠癌
腹腔镜
免疫功能
Rectal cancer
Laparoscope
Immune function
