期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

miR-126与心血管疾病关系的研究进展 被引量：5

Current research and progress of miR-126 effects in cardiovascular diseases
原文传递
导出
摘要 微小核糖核酸(microRNAs,miRNA)是一类内源性高度保守的非编码小分子RNA,其可通过降解信使RNA并抑制其翻译在转录水平调控靶基因的表达,参与细胞生长、发育、分化和增殖等多个生命过程。MicroRNAs-126(miR-126)是一种内皮特异性miRNA,与高血压、动脉粥样硬化、冠心病、心力衰竭等心血管疾病密切相关。近期研究表明,miR-126能显著影响心血管疾病的发生、发展和疾病的预后。本文就miR-126与心血管疾病的关系进行综述。 MicroRNAs （miRNAs, miRNA） are a class of endogenous highly conserved, small, noncoding RNA molecules, which control the expression of genes at the post-transcriptional level through degradation of messenger RNA and inhibits its translation. They are involved in cell growth, development, differentiation, proliferation and other life processes. miR-126 is a kind of specific miRNA, which is closely related to hypertension, atherosclerosis, coronary heart disease, heart failure and other cardiovascular diseases. Recent studies have shown that miR-126 can significantly affect the incidence and development of cardiovascular diseases. More so, it can also influence the prognosis of cardiovascular diseases. In this paper, the relationship between miR-126 and cardiovascular diseases was reviewed.
作者 李国达 刘衍宇 方凌燕
机构地区 广东医学院研究生院 广东医学院第二附属医院心血管内科
出处 《心脏杂志》 CAS 2014年第6期724-726,733,共4页 Chinese Heart Journal
关键词 microRNA-126 高血压 动脉粥样硬化 冠状动脉疾病 心力衰竭 microRNA-126 hypertension atherosclerosis coronary disease heart failure
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献22

  • 1Friedman RC, Farh KK, Burge CB, et al. Most mammalian mRNAs are conserved targets of microRNAs [ J ]. Genome Res, 2009, 19 (1) :92 -105.
  • 2Fish JE, Santoro MM, Morton SU, et al. miR-126 regulates angio- genic signaling and vascular integrity[ J ]. Dev Cell, 2008, 15 (2) : 272 - 284.
  • 3Synetos A, Toutouzas K, Stathogiannis K, et al. MicroRNAs in ar- terial hypertension [ J ]. Curr Top Med Chem, 2013, 13 ( 13 ) : 1527 - 1532.
  • 4Sober S, Laan M, Annilo T, et al. MicroRNAs miR-124 and miR- 135a are potential regulators of the mineralocorticoid receptor gene (NB.3C2) expression [ J ]. Biochem Biophys Res Commun, 2010, 391 ( 1 ) :727 -732.
  • 5王艺璇,刘媛圆,李明瑛,刘秀兰,高飞,杨新春,蔡军.microRNA作为高血压病治疗靶点的初步实验研究[J].山东医药,2012,52(4):11-13. 被引量：13
  • 6Harris TA, Yamakuchi M, Ferlito M, et al. MicroRNA-126 regu- lates endothelial expression of vascular cell adhesion molecule 1 [ J ]. Proc Natl Acad Sci USA, 2008 ,105(5) :1516 -1521.
  • 7Harris TA, Yamakuchi M, Kondo M, et al. Ets-1 and Ets-2 regu- late the expression of micmRNA-126 in endothelial cells [ J]. Arte- rioscler Thromb Vasc Biol, 2010, 30(10) :1990 -1997.
  • 8Hulsmans M, Holvoet P. MicroRNA regula- ting inflammation in association with atherosclerotic disease [ J ]. Cardiovascular Research, 2013, 100( 1 ) :7 - 18.
  • 9Zemecke A, Bidzhekov K, Noels H, et al. Delivery of microR- NA126 by apoptotic bodies induces CXCL12-dependent vascular protection [ J ]. Sci Signal, 2009, 2 (100) : ra81.
  • 10Weber C, Schober A, Zemecke A, et al. MicroRNAs in arterial re- modelling, inflammation and atherosciemsis [ J ]. Curr Drug Tar- gets, 2010,11(8) :950 -956.

二级参考文献12

  • 1Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis [J]. Dev Cell, 2008,15(2) :261-271.
  • 2Harris TA, Yamakuchi M, Ferlito M, et al. MieroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1 [ J ]. Proc Nail Aead Sei USA, 2008,105 (5) :1516-1521.
  • 3Stumpf C, John S, Jukic J, et 81. Enhanced levels of platelet P-seleetin and circulating eytokines in young patients with mild arterial hypertension [J]. J Hypertens, 2005,23(5):995-1000.
  • 4Tavazoie SF, Alarcon C, Oskarsson T, et al. Endogenous human microRNAs that suppress breast cancer metastasis [ J ]. Nature, 2008,451 (7175) : 147-152.
  • 5Fulci V, Colombo T, Chiaretti S, et al. Characterization of B- andT-lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles [ J ]. Genes Chromosomes Cancer, 2009,48(12) :1069-1082.
  • 6Wilson EM, Diwan A, Spinale FG, et al. Duality of innate stress responses in cardiac injury, repair, and remodeling [J]. J Mol Cell Cardiol, 2004,37(4) :801-811.
  • 7Moon SK, Cha BY, Kim CH. ERK1/2 mediates TNF-alphainduced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1 : Involvement of the ras dependent pathway [ J]. J Cell Physiol, 2004, 198(3) :417-427.
  • 8Coles B, Fielding CA, Rose-John S, et al. Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin 1/-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo [ J ]. Am J Pathol, 2007,171 ( 1 ) :315-325.
  • 9Shesely EG, Maeda N, Kim HS, et al. Elevated blood pressures in mice lacking endothelial nitric oxide synthase [ J ]. Proc Nail Acad Sci USA, 1996,93(23) :13176-13181.
  • 10Gelinas DS, Bernatchez PN, Rollin S, et al. Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways [J]. Br J Pharmacol, 2002,137 (7) : 1021-1030.

共引文献12

同被引文献33

  • 1Adam M Noyes,Kirandeep Dua,Ramprakash Devadoss,Lovely Chhabra.Cardiac adipose tissue and its relationship to diabetes mellitus and cardiovascular disease[J].World Journal of Diabetes,2014,5(6):868-876. 被引量：8
  • 2Wang SS, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis[ J]. Dev Cell, 2008, 15(2) :261 -271.
  • 3Chen JJ, Zhou SH. Mesenchymal stem ceils over expressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway [J]. Cardiol J, 2011, 18(6) :675 -681.
  • 4Kane NM, Meloni M, Spencer HL, et al. Derivation of endothelial cells from human embryonic stem ceils by directed differentiation: analysis of mieroRNA and angiogenesis in vitro and in vivo[J]. Arte- rioscler Thromb Vasc Biol, 2010, 30 ( 7 ) : 1389 - 1397.
  • 5Harris TA, Yamakuchi M, Ferlito M, et al. MicroRNA-126 regulatesendothelial expression of vascular cell adhesion molecule 1 [ J ]. Proc Natl Acad Sci USA, 2008, 105 (5) : 1516 - 1521.
  • 6Lassaletta AD, Elmadhun NY, Burgess TA, et al. Microvascular notch signaling is upregulated in response to vascular endothelial growth factor and chronic myocardial ischemia[ J] . Circ J, 2014, 78(3) :743 -751.
  • 7Fish JE, Santoro MM, Morton SU, et al. MiR-126 regulates angio- genic signaling and vascular integrity[ J]. Dev Cell, 2008, 15 ( 2 ) : 272 - 284.
  • 8张冬梅,吴爱明,娄利霞,吕晞滢,李耀辉,王硕仁.活血益气方对心梗后大鼠缺血心肌血管新生及VEGF表达的影响[J].辽宁中医杂志,2010,37(8):1602-1604. 被引量：16
  • 9刘芬,娄远蕾,阮琼芳,谢安,李勇,崔苏萍,汪泱.内皮细胞缺氧后miR-210、miR-92a、miR-126表达及意义[J].山东医药,2011,51(39):4-5. 被引量：4
  • 10郑志伟,劳海燕,余细勇,陈纪言,林秋雄,麦丽萍,钟诗龙.冠心病患者血浆循环miR-126的表达及其对血管内皮细胞的影响[J].中国病理生理杂志,2011,27(12):2313-2317. 被引量：18

引证文献5

二级引证文献22

心脏杂志
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部