摘要
目的早期识别手足口病的重症化风险,改进治疗效果,减少死亡病例。方法回顾性分析2012年住院治疗的503例手足口病患儿临床特征和实验室检测结果,将患儿分为一般病例(轻症组)和重症病例(重症组),采用MedCalc 9.6.2.0软件统计分析。结果 503例手足口病患儿中重症组80例、轻症组423例,患儿体温39℃以上、呕吐、肢体抖动的发生率重症组分别为75.0%、31%、81.3%,均高于轻症组的26.0%、6.4%、9.7%,差异有统计学意义(P<0.05);平均住院时间重症组(12.0±4.0)d,显著高于轻症组的(5.0±3.0)d(P<0.0001);轻症组与重症组的白细胞、淋巴细胞、中性粒细胞、肌酸激酶、肌酐和EV71/CoxA16的阳性率比较,差异均有统计学意义(P<0.05)。结论体温39℃以上、呕吐、肢体抖动、淋巴细胞及肌酸激酶水平升高和EV71的感染,为手足口病患儿重症化的危险因素。
OBJECTIVE To identify the risk of severe hand ,foot ,and mouth disease in early stage and improve the curative effect so as to reduce the mortality .METHODS The clinical characteristics and the results of clinical labo‐ratory examination of 503 children with hand ,foot ,and mouth disease who were hospitalized for treatment in 2012 were retrospectively analyzed ;the children were divided into the general case group （the mild group） and the severe case group （the severe group） ,and the statistical analysis was performed with the use of MedCalc9 .6 .2 .0 software .RESULTS The 503 children with hand ,foot ,and mouth disease included 80 severe cases and 423 mild cases;the children with the body temperature more than 39 ℃ accounted for 75 .0% in the severe group ,26 .0%in the mild group ;the children with vomiting accounted for 31% in the severe group ,6 .4% in the mild group;the children with limb trembling accounted for 81 .3% in the severe group ,9 .7% in the mild group ,there were statis‐tically significant differences（P〈 0 .05） .The average hospitalization duration of the severe group was （12 .0 ± 4 .0）days ,significantly longer than （5 .0 ± 3 .0）days of the mild group （P〈0 .0001） .As compared with the posi‐tive rates of the whiter blood cells ,lymphocytes ,neutrophils ,creatine kinase ,creatinine ,and EV71/CoxA16 , there were statistically significant differences between the severe group and the mild group （ P 〈 0 .05 ） . CONCLUSION The more than 39℃ of body temperature ,vomiting ,limb trembling ,elevated levels of lymphocytes and creatine kinase ,and EV71 infection are the risk factors for severe hand ,foot ,and mouth disease in the children .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第22期5688-5690,共3页
Chinese Journal of Nosocomiology
基金
国家科技支撑计划专项基金资助项目(2012BAI37B00)
关键词
手足口病
肠道病毒EV71
临床特征
Hand,foot,and mouth disease
Enterovirus 71
Clinical characteristic
