摘要
目的：探讨成纤维细胞激活蛋白（ FAP）在甲状腺乳头状癌（ PTC）中的表达及意义。方法：采用免疫组织化学 SP 法检测66例2010年1月～2013年10月间收集的甲状腺乳头状癌和10例正常甲状腺中的表达情况。结果：FAP 在甲状腺乳头状癌间质成纤维细胞中表达，阳性率为86．36％；而在正常甲状腺间质及PTC癌细胞中不表达。甲状腺乳头状癌间质中FAP 表达与肿瘤TNM分期（χ^2＝20．823，P＜0．01）及淋巴结转移（χ^2＝11．853，P＜0．01）有关。结论：PTC间质中FAP的表达对PTC的侵袭、转移具有较好的预测价值。
Objective：To investigate the expression and significance of fibroblast activation protein （ FAP） in mesenchyme of papillary thyroid carcinoma （PTC）.Methods：Immunochemical S-P method was used to detect the expression of FAP in 66 cases diagnosed as PTC between Jan.2010 and Oct.2013 and another 10 subjects with normal thyroid.Results：FAP was positively expressed in 86.36% of the PTC cases and free in the normal subjects,and ex-pression of FAP was associated with staging of TNM （χ^2 =20.823,P〈0.01）as well as lymph node metastasis （χ^2 =11.853,P〈0.01）.Conclusion：FAP expression in stromal fibroblasts may signal the invasion degree and tumor metastasis of PTC ,thus detection of this protein can be of valuable estima-tion of the prognosis of this entity .
出处
《皖南医学院学报》
CAS
2014年第5期386-388,共3页
Journal of Wannan Medical College
