摘要
目的观察新诊断T2DM患者短期胰岛素泵强化降糖治疗后影响血糖长期控制的因素。方法选取新诊断T2DM患者32例,胰岛素泵治疗2周,测定治疗前后OGTT 0.5、1、2hPG及Ins,计算胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)和第一时相胰岛素分泌(ΔI30/ΔG30)。观察3年后血糖控制情况,分析影响因素。结果胰岛素泵强化治疗后,FPG、0.5hPG、2hPG、HOMA-IR均较治疗前下降,HOMA-β和ΔI30/ΔG30升高(P<0.01)。3年后血糖控制率为28.1%(9/32)。Logistic回归分析显示,强化治疗后有氧运动是血糖长期控制的重要因素(OR=24,P<0.05)。结论新诊断T2DM患者短期胰岛素泵强化治疗可长期控制血糖,有氧运动是血糖长期控制的重要因素。
Objective To observe the effect of insulin pump therapy on long-term glycemic control in newly diagnosed type 2 diabetic patients and its influencing factors.Methods 32 patients with newly diagnosed type 2 diabetes were treated with continuous subcutaneous insulin infusion （CSⅡ） therapy for 2 weeks.75 g OGTT 0.5,1,2 hPG and Ins were measured,and HOMA-β,HOMA-IR,and early-stage insulin secretion index （△I30/△G30） were calculated before and after treatment.A long-term glycemic control for≥ 3 years was defined as control and the non-long-term glycemic control as hyperglycemia relapse.Results After CSⅡ,the level of FPG,0.5 hPG,2 hPG,HOMA-IR was lower after treatment than before treatment,and HOMA-β and △I30/△G30 was higher（P〈0.01）.The control rate of blood glucose was 28.1% （9/32）.Logistic regression analyses showed that after CSⅡ,aerobic exercise was independent predictor of long term glucose control （OR=24,P〈0.05）.Conclusion Newly diagnosed T2DM patients with short-term intensive insulin pump therapy can relieve diabetes for a long time,aerobic exercise after CSⅡ therapeutic schedule is a convenient and significant predictor for long term diabetes control.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2014年第11期994-996,共3页
Chinese Journal of Diabetes
关键词
糖尿病
2型
持续胰岛素皮下输注
有氧运动
Diabetes mellitus, type 2
Continuous subcutaneous insulin infusion（CSⅡ）
Aerobic exercise
