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丙泊酚及其代谢物血药浓度分析方法研究进展 被引量：6

Research progress of analytical methods for the determination of Propofol and its metabolites in blood
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摘要 丙泊酚是一种短效、速效静脉麻醉剂。由于丙泊酚起效极快且麻醉后舒适感较好,因此广泛用于临床。本文对丙泊酚及其代谢物血药浓度分析方法的研究现状做一综述,讲述了几种定量分析方法,主要有液相色谱法(LC)、气相色谱/质谱联用技术(GC/MS)或液相-串联质谱技术(LC-MS/MS)。分别阐述了各方法的特点及应用前景,并提出了今后丙泊酚及其代谢物分析方法的发展方向。 Propofol is a short-acting, fast-acting intravenous anesthetic. Because of Prppofol anesthesia fast and the patients feel comfortable after anesthesia, so it is widely used in clinical surgery. This review reports on the analytical methods for the determination of Propofol and its metabolites in blood, including liquid chromatography （LC）, gas chromatography/mass spectrometry （GC/MS）, or LC coupled with tandem mass spectrometry（LC-MS/MS）. Method＇s fea-tures,application prospects and technical developments are also discussed.
作者 李莉 李培
机构地区 新疆医科大学药学院
出处 《中国医药导报》 CAS 2014年第32期160-164,共5页 China Medical Herald
基金 新疆维吾尔自治区自然科学基金项目(编号2014211C010)
关键词 丙泊酚 血药浓度 分析方法 进展 Propofol Concentration in blood Analysis Research
分类号 R969.1 [医药卫生—药理学]
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参考文献29

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二级参考文献45

共引文献61

同被引文献73

  • 1徐富星,季大年.无痛苦消化内镜技术临床应用现况[J].中国实用内科杂志,2005,25(3):221-222. 被引量：77
  • 2夏东亚,许霁虹,王彦,郭涛,张铁铮.高效液相色谱法测定丙泊酚血药浓度[J].解放军药学学报,2005,21(3):229-231. 被引量：11
  • 3朱友江,丁轩坤.血液中丙泊酚的GC-MS分析[J].法医学杂志,2006,22(4):313-314. 被引量：5
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引证文献6

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中国医药导报
2014年 第32期

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