摘要
目的:了解住院2型糖尿病患者甲状腺功能状态。方法:回顾性分析2009年5月至2011年12月安徽省立医院内分泌科住院治疗的805例2型糖尿病患者和226例正常对照组的甲状腺功能状态。结果:1)2型糖尿病患者甲状腺功能异常患病率为20.12%,其中甲亢、亚临床甲亢、甲减、亚临床甲减患病率分别为1.99%、2.86%、2.24%、13.04%;2型糖尿病患者合并甲状腺功能异常及亚临床甲减的患病率显著高于正常对照组(分别为10.18%和4.87%)(P<0.05);女性患者甲状腺功能异常及亚临床甲减患病率均显著高于男性(P<0.01)。2)2型糖尿病患者亚临床甲减的患病率随年龄的增加而升高(P<0.05),但未发现与糖尿病病程有关;抗体阳性(TPOAb或TGAb阳性)组的患者亚甲减患病率亦显著高于抗体阴性(TPOAb和TGAb均阴性)组。结论:2型糖尿病患者甲状腺功能异常的发生率高,尤其是女性和55岁以上的2型糖尿病患者亚甲减发生率更高,建议筛查女性及55岁以上2型糖尿病患者的甲状腺功能。
Objective： To investigate the changes of thyroid function in patients with type 2 diabetes mellitus. Methods： A retrospective study in serum thyroid function was carried out among 805 diabetic patients in Anhui provincial hospital and 226 controls. Results： 1） The prevalence of type 2 diabetes patients with abnormal thyroid function was 20.12% and their respective prevalence were： hyperthyroidism（1.99%）, subclinical hyperthyroidism（2.86%）, hypothyroidism（2.24%）, subclinical hypothyroidism（13.04%）; The prevalence of abnormal thyroid function and subclinical hypothyroidism in type 2 diabetes patients were significantly higher than those in the normal group（10.18% and 4.87%, respectively（P〈0.05）; The prevalence of thyroid dysfunction and subclinical hypothyroidism in female patients were significantly higher than that in males（P〈0.01）; 2） The prevalence of subclinical hypothyroidism increased with the increasing age in type 2 diabetes, but the association of which with the duration of diabetes was not found. The incidence of subclinical hypothyroidism in antibody positive（TPOAb or TGAb was positive） patients was significantly higher than that in negative patients（TPOAb and TGAb were negative）. Conclusion： Prevalence of abnormol thyroid function is quite high in type 2 diabetes mellitus, especially in female and patients above 55 years, who we suggest thyroid funcion should be checked out in.
出处
《临床与病理杂志》
CAS
2014年第5期525-529,共5页
Journal of Clinical and Pathological Research
