摘要
目的：观察拉贝洛尔联合硫酸镁治疗中重度妊娠期高血压疾病的临床疗效及安全性。方法78例中重度妊娠期高血压疾病患者按照随机数字表法分为对照组和观察组各39例，对照组单用硫酸镁治疗，观察组在应用硫酸镁基础上联合拉贝洛尔治疗，观察两组患者治疗前后平均收缩压和舒张压、24 h尿蛋白、孕产妇心率、胎心率和治疗后母婴结局情况。结果观察组治疗后收缩压（134．5±9．7） mmHg和舒张压（85．7±5．9）mmHg，较对照组的（145．2±10．8）mmHg、（96．1±6．8）mmHg显著下降（t＝4．60、7．21，均P＜0.05）；两组24 h尿蛋白、心率及胎心率等差异均无统计学意义（t＝0．52、0．56、0．15，均P＞0．05）；治疗后终止妊娠（7．7％）、胎盘早剥（0．0％）、胎儿窘迫（5．1％）、新生儿窒息发生率（7．7％）、产后出血（12．8％）、低体质量儿（12．8％）均显著低于对照组（33．3％、12．8％、20．5％、25．6％、33．3％、35．9％）（χ^2=7．86、5．34、4.13、4．52、4．62、5．64，均P＜0．05）；观察组治疗后总有效率94．9％，明显高于对照组的79．5％（χ^2=4．13，P＜0.05）；观察组不良反应的发生率15．4％，明显低于对照组的35．9％（χ^2=4．30，P＜0．05）。结论拉贝洛尔联合硫酸镁治疗中重度妊娠期高血压疾病效果满意，能有效降低平均血压，减少24 h尿蛋白含量，改善母婴结局，值得临床推广应用。
Objective To observe the clinical effect and safety of labetalol combined with magnesium sulfate in treating moderate and severe pregnancy-induced hypertension disease.Methods 78 cases with moderate and severe pregnancy-induced hypertension disease were divided into the control group and observation group according to random number table method,39 cases were in each group.The patients in the control group were given the magnesi-um sulfate only,and the patients in the observation group were given the treatment of labetalol combined with magnesi-um sulfate.After treatment,the average blood pressure,24h urine protein,maternal heart rate,fetus heart rate and pregnancy outcomes were detected.Results After treatment,the average blood pressure[（134.5 ±9.7） vs （85.7 ± 5.9）]mmHg of observation group was significantly lower than the control group（t=4.60,7.21,all P〈0.05）;the 24h urine protein,maternal heart rate and fetus heart rate had no significant difference （t=0.52,0.56,0.15,all P〉0.05）;the termination of pregnancy（7.7%）,placental abruption（0.0%）,fetal distress（5.1%）,incidence of neo-natal asphyxia（7.7%）,postpartum hemorrhage（12.8%）,low birth weight（12.8%） were significantly lower than the control group（33.3%,12.8%,20.5%,25.6%,33.3%,35.9%） （χ^2=7.86,5.34,4.13,4.52,4.62,5.64,all P〈0.05）;the total effective rate of observation group with 37 cases （94.9%） was significantly higher than the con-trol group with 31 cases （79.5%） （χ^2=4.13,P〈0.05）;the incidence of adverse reactions of observation group with 15.4%was significantly lower than the control group with 35.9%（χ^2=4.30,P〈0.05）.Conclusion Labe-talol combined with magnesium sulfate in treating moderate and severe pregnancy-induced hypertension disease could effectively reduce the average blood pressure,the 24h urine protein and improve the pregnancy outcomes,which was worthy of clinical popularization and application.
出处
《中国基层医药》
CAS
2014年第22期3455-3458,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
妊娠期高血压疾病
拉贝洛尔
硫酸镁
Pregnancy-induced hypertension disease
Labetalol
Magnesium sulfate
