期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

新生儿脑损伤预后具有性别差异的机制

原文传递
导出
摘要 各种严重新生儿疾病引起的脑损伤可能造成不同程度的神经系统后遗症，表现为智力低下、认知功能障碍和行为、运动障碍等。决定远期预后的因素很多，其中性别差异导致的临床预后不同越来越引起人们的重视动物研究发现，缺氧缺血性脑病（hypoxic—ischemic encephalopathy，HIE）幼鼠在结构和行为功能上的缺陷与人类类似。
作者 龙莎莎 林碧云 王来栓
机构地区 复旦大学附属儿科医院新生儿科
出处 《中华围产医学杂志》 CAS 北大核心 2014年第11期786-789,共4页 Chinese Journal of Perinatal Medicine
关键词 新生儿脑损伤 性别差异 远期预后 神经系统后遗症 缺氧缺血性脑病 认知功能障碍 行为功能 新生儿疾病
分类号 R722.1 [医药卫生—儿科]
  • 相关文献

参考文献38

  • 1Hill CA, Fitch RH. Sex differences in mechanisms and outcome of neonatal hypoxia-ischemia in rodent models: implications for sex-specific neuroprotection in clinical neonatal practice[J]. Neurol Res Int, 2012, 2012:867531.
  • 2Simon NP. Long-term neurodevelopmental outcome of asphyxiated newborns[J]. Clin Perinatol, 1999, 26:767-778.
  • 3Hill CA, Threlkeld SW, Fitch RH. Early testosterone modulated sex differences in behavioral outcome following neonatal hypoxia ischemia in rats[J]. Int J Dev Neurosci, 2011, 29:381- 388.
  • 4Sakuma Y. Gonadal steroid action and brain sex differentiation in the rat[J]. J Neuroendocrinol, 2009, 21:410-414.
  • 5Hines M. Early androgen influences on human neural and behavioural development[J]. Early Hum Dev,2008,34:850-807.
  • 6Loidl CF, Gavilanes AW, Van Dijk EH, et al. Effects of hypothermia and gender on survival and behavior after perinatal asphyxia in rats[J]. Physiol Behav, 2000,68:263-269.
  • 7Recker R, Adami A, Tone B, et al. Rodent neonatal bilateral carotid artery occlusion with hypoxia mimics human hypoxic ischemic injury[J]. J Cereb Blood Flow Metab, 2009, 29:1305-1316.
  • 8Golomb MR, Fullerton H J, Nowak-Gottl U, et al. Male predominance in childhoodischemic stroke: findings from the international pediatric stroke study[J]. Stroke, 2009, 40:52-57.
  • 9McCarthy MM. Estradiol and the developing brain[J]. Physiol Rev, 2008, 88:91-124.
  • 10Liu F, Yuan R, Benashski SE, et al. Changes in experimental stroke outcome across the life span[J]. J Cereb Blood Flow Metab, 2009, 29:792-802.

二级参考文献38

  • 1Terada K, Inae S, Mizutani N, et al. Cerebral blood flow, glucose metabolism and tunel-positive cells in the development of ischemia.Cerebrovasc Dis, 2001, 11 (1): 9
  • 2Koizumi J, Yoshida Y, Nakazawa T, et al. Experimental studies of ischemic brain edema: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke, 1986, 8:1
  • 3Garcia JH, Liu K, Ho K. Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex. Stroke, 1995; 26:636
  • 4Dimagl U, Iadecola C, Moskowitz MA. Pathobiology of ischemic stroke: an integrated view. Trends Neurosic, 1999, 22(9): 391
  • 5Marlangue CC, Represa MA, Popcvici T, et al. Apoptosis and necrosis after reversible focal ischemia: An in situ DNA fragmentation analysis. J Cereb Blood Flow Metab, 1996, 27:186
  • 6Yagita Y, Matsumoto M, Kitagawa K, et al. DNA cleavage and proteolysis of microtubute-associated protein 2 after cerebral ischemia of different severity. Neuroscience, 1999, 92(4): 1417
  • 7Jin K, Chen J, Nagayama T, et al. In situ detection of neuronal DNA strand breaks using the Klenow fragment of DNA polymerase I reveals different mechanisms of neuron death after cerebral ischemia.J Neurochem, 1999, 72(3): 1204
  • 8Nagayama T, Lan J, Henshall DC, et al. Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia. J Neurochem, 2000, 75(4): 1716-28
  • 9Cui J, Holmes EH, Greene TG, et al. Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. J FASEB, 2000, 14(7): 955
  • 10Wiessner C, Sauer D, Alaimo D, et al. Protective effect of a caspase inhibitor in models for cerebral ischemia in vitro and in vivo.Cell Mol Biol (Noisy-lc-grand), 2000, 46(1): 53

共引文献21

中华围产医学杂志
2014年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部