摘要
目的探讨老年高血压患者动脉硬化的危险因素,为早期预防心脑血管疾病提供临床依据。方法选择老年高血压患者88例,进行无创性动脉硬化监测和血压、血生化指标测定,分别按臂踝脉搏波传导速度(brachialankle pulse wave velocity,baPWV)和踝臂指数(ankle-brachial index,ABI)分为2组:baPWV增高组46例和baPWV正常组42例,ABI低值组38例和ABI正常组50例。结果与baPWV正常组比较,baPWV增高组收缩压[(154.78±18.56)mm Hg vs(146.29±17.64)mm Hg,1mm Hg=0.133kPa]、TG[(1.99±0.42)mmol/L vs(1.77±0.34)mmol/L]、LDL-C[(3.07±0.52)mmol/L vs(2.51±0.44)mmol/L]、空腹血糖[(6.58±2.39)mmol/L vs(5.38±2.25)mmol/L]明显增高,差异有统计学意义(P<0.05,P<0.01)。ABI低值组高血压病程、收缩压、TG、LDL-C、空腹血糖明显高于ABI正常组(P<0.01)。多元逐步回归分析表明,高血压病程、收缩压、LDL-C、空腹血糖是老年高血压患者动脉硬化指标baPWV、ABI异常的独立危险因素。结论长病程、高血压、高胆固醇血症、高血糖与baPWV、ABI密切相关,促进老年高血压患者动脉硬化的发生、发展。
Objective To provide the clinical evidence for early prevention of cardio-cerebrovascular diseases in elderly hypertensive patients by studying the risk factors for their arteriosclerosis.Methods Eighty-eight elderly hypertensive patients were divided into high baPWV group （n=46） and normal baPWV group （n=42）,or into low ABI group （n=38） and normal ABI group （n=50）.Their arteriosclerosis was detected and their blood pressure was measured using noninvasive method.Results The systolic blood pressure,serum levels of TG,LDL-C and fasting blood glucose were significantly higher in high baPWV group than in normal baPWV group （154.78± 18.56 mm Hg vs 146.29±17.64 mm Hg,1.99±0.42 mmol/L vs 1.77±0.34 mmol/L,3.07± 0.52 mmol/L vs 2.51±0.44 mmol/L,6.58±2.39 mmol/L vs 5.38±2.25 mmol/L,P＜0.05,P＜0.01）.The duration of hypertension was significantly longer,and the systolic blood pressure,serum levels of TG,LDL-C and fasting blood glucose were significantly higher in low ABI group than in normal ABI group （P＜0.05,P＜0.01）.Multiple stepwise regression analysis showed that duration of hypertension,systolic blood pressure,and serum LDL-C and fasting blood glucose level were the independent risk factors for arteriosclerosis in elderly hypertensive patients.Conclusion Long duration of hypertension,hypertension,hypercholesterolemia and hyperglycemia are closely related with baPWV and ABI,thus promoting the occurrence and progress of arteriosclerosis in elderly hypertensive patients.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2014年第11期1151-1153,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
山东省医药卫生科技发展计划项目(2009-7)
