摘要
目的:观察质子泵抑制剂(PPI)联合莫沙必利、黏膜保护剂对反流性食管炎(RE)的临床疗效。方法:将136例确诊为RE的患者作为研究对象,随机分为治疗组68例和对照组68例,治疗组患者给予雷贝拉唑联合莫沙必利和黏膜保护剂治疗,对照组患者给予雷贝拉唑联合莫沙必利治疗,治疗8周后比较两组患者治疗效果。结果:治疗组患者的症状改善有效率高于对照组,差异有统计学意义(P<0.05);经内镜检查,治疗组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。结论:临床药物治疗RE时PPI联合莫沙必利、黏膜保护剂可显著提高患者的临床疗效。
Objective To investigate clinical efficacy of proton pump inhibitor （PPI） combined with Mosapride, mucosal pro-tective drugs in reflux esophagitis （RE）. Methods： 136 cases with confirmed RE were randomly divided into two groups： PPI com-bined with Mosapride, mucosal protective drugs treatment group （68 cases） and PPI combined with Mosapride group （68 cases）. 8weeks after the treatment,the efficacies of the two groups were compared. Results： After 8-week treatment, the total effective rate ofsymptom improvement in the treatment group was significantly higher than that in the control group, and the difference was statisticallysignificant （P〈0. 05）. By endoscopy, the total effective rate in the treatment group was significantly higher than that in the controlgroup, and the difference was statistically significant （P〈0. 05）. Conclusions： PPI combined with Mosapride, mucosal protectivedrugs can raise the RE clinical efficacy significantly.
出处
《中国民康医学》
2014年第24期29-30,32,共3页
Medical Journal of Chinese People’s Health
关键词
质子泵抑制剂
莫沙必利
黏膜保护剂
反流性食管炎
Proton pump inhibitor（PPI）
Mosapride
Mucosal protective drugs
Reflux esophagitis
