摘要
目的观察参芪益气通脉颗粒对病态窦房结综合征家兔模型心率、窦房结传导时间的影响。方法用45只健康家兔进行改进方法 SSS造模,挑选32只造模成功家兔随机分组:参芪益气通脉颗粒组,心宝丸组,生理盐水组。分别在给药前,实验开始后3 d、1周、2周测量心率(HR);于给药前、试验开始后1周、2周则量窦房传导时间(SACT)。实验结束时对比各组疗效。结果参芪益气通脉颗粒组HR,SACT的改善情况均优于对照组。参芪益气通脉颗粒可明显加快心率(P<0.05,P<0.01),但与心宝组比较差异无统计学意义。参芪益气通脉颗粒可明显缩短SACT(P<0.05,P<0.01),且10 g/kg组药后30 min作用优于心宝组(P<0.05)。结论参芪益气通颗粒对病态窦房结综合征家兔模型可降低心肌细胞的自律性,调节心脏传导系统功能,通过多途径、多环节、多靶点阻断心律失常的发生,因而有很好的抗心律失常功能。
Objective To observe the effect of Shenqi Yiqi Tongmai Granules on the heart rates and sinus node conduction time of rabbits with sick sinus syndrome. Methods 45 healthy rabbits were used to set up the model with SSS. 32 rabbits were randomly divided into Shenqi Yiqi Tongmai Granules group,Xinbao Pills group and physiological saline group. The heart rates（ HR） were measured before the drug delivery and 3 days,1 week,2 weeks after the experiment. Sinoatrial conduction time（ SACT） is measured before the drug delivery and 1 week,2 weeks after the experiment. The curative effects of these groups were compared after the experiment. Results The improvement of HR and SACT in Shenqi Yiqi Tongmai Granules group was better than that of control group. Shenqi Yiqi Tongmai Granules can accelerate heart rate（ P〈0. 05,P〈0. 0l）. There is no obvious difference between Shenqi Yiqi Tongmai Granules group and Xinbao Pills group. Shenqi Yiqi Tongmai Granules can shorten SACT（ P〈0. 05,P〈0. 0l）. The function of drug pairs of 10 g /kg is better than that of Xinbao Pills group. Conclusion Shenqi Yiqi Tongmai Granules for rabbits with sick sinus syndrome can reduce the self-discipline of myocardial cells and regulate the function of cardiac conduction system. It can block the occurrence of arrhythmia and has good anti-arrhythmic function.
出处
《吉林中医药》
2014年第11期1163-1166,共4页
Jilin Journal of Chinese Medicine
基金
黑龙江省中医药科研项目:参芪益气通脉颗粒对病窦综合征的临床研究(ZHY10-Z56)
