摘要
目的观察多索茶碱对支气管哮喘患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)水平和肺功能的影响。方法将72例急性发作期支气管哮喘患者随机均分为两组,治疗组采用多索茶碱治疗,对照组采用氨茶碱治疗,治疗前后观察血清细胞因子(TNF-α、IL-10)、肺功能的变化。结果与治疗前比较,两组治疗后的TNF-α水平明显下降,治疗组下降更明显(P<0.01);两组治疗后的血清IL-10水平均明显上升,治疗组上升更明显(P<0.01);两组治疗后的肺功能指标明显改善,且治疗组改善更明显(P<0.01)。结论多索茶碱可降低TNF-α水平、上调IL-10水平,从而抑制气道炎症、缓解气道痉挛、降低气道高反应性,改善肺功能。
Objective To observe the influence of doxofylline on serum TNF-α, serum TNF-α,IL-10 level and lung function in patients with bronchial asthma. Methods 72 patients with acute episode bronchus asthma were randomly divided into the two groups,the treatment group was given doxofylline and the control group was given aminophylline.The change of serum cytokines（TNF-α and IL-10）and lung function were observed before and after the treatment. Results Compared with before treatment,serum TNF-α level decreased obviously in the two groups,the treatment group dropped more obviously（P 〈0.01）,IL-10 level are increased obviously,the treatment group rised more obviously（P 〈0.01）,lung function indicators of two groups after treatment significantly improved,and the treatment group improve significantly（P〈0.01）. Conclusion Doxofylline can reduce the TNF-α level,raise IL-10 level to inhibit airway inflammation,relieve airway spasms,lower airway responsieness,improve lung function.
出处
《中国当代医药》
2014年第33期28-30,共3页
China Modern Medicine
