摘要
目的观察不同剂量的米非司酮治疗子宫肌瘤的临床效果。方法绍兴市柯桥区齐贤医院2012年2月15日至11月15日共接收患有子宫肌瘤的患者105例,将其平均分为A、B、C组,每组35例。A组给予正常剂量米非司酮25mg/d,B组给予小剂量米非司酮12.5mg/d,C组给予最小剂量5mg/d。所有病患须在月经开始第3天服用米非司酮,连续服用12周为1个疗程,比较3组患者服药前后子宫体积、子宫肌瘤体积、各项激素水平,包括血清卵泡刺激素(FSH),黄体生成素(LH),雌激素(E_2),孕酮(P)等指标的变化及不良反应。结果接受1个疗程治疗后,全部患者经过B超检查其子宫和子宫肌瘤的体积均有不同程度变小,3组患者问子宫和子宫肌瘤体积缩小率组间有显著性差异(F值分别为613.106和548.191,均P<0.001),其中小剂量B组缩小体积较为显著,子宫肌瘤体积治疗前后缩小率为65.2%,子宫体积缩小率为61.9%;正常剂量A组缩小率分别为36.4%和33.1%;最小剂量C组缩小率分别为34.6%和31.3%。3组激素水平(FSH、LH、E_2、P)指标均有降低,与治疗前相比,治疗后E_2、P水平显著降低(F值分别为16.713和20.968,均P<0.01)。3组患者的不良反应均不明显。结论小剂量米非司酮连续使用12周治疗子宫肌瘤临床效果较佳。
Objective To observe the clinical effect of different doses of mifepristone on the treatment of uterine fibroid.Methods Totally 105 patients with uterine fibroids were treated at Qixian Town’s Community Health Service of Shaoxing during the period of February 15, 2012 to November 15, 2012.They were divided into three equal groups with 35 cases： group A, group B and group C.Normal dose （25mg/d） was given to group A, small dose （12.5mg/d） was given to group B, and minimum dose （5mg/d） was given to group C.All patients started to take mifepristone at the third day of menstruation, and 12 continuous weeks was considered as a treatment course.The changes of patients’ uterine volume, hysteromyoma volume and hormone levels （ including FSH, LH, E2 and P） were measured.Their adverse reactions were analyzed as well.Results B-ultrasound examination indicated that all patients’ uterus and uterine fibroid volume diminished in different degree after one treatment course.The volume reduction ratio of uterus and uterine fibroids was significantly different among three groups （F value was 613.106 and 548.191, respectively, both P〈0.001）.The reduction ratio of group B was great.The reduction ratio of uterine fibroid was 65.2%, and that of uterus was 61.9%.The reduction ratio of uterine fibroid and uterus of group A was 36.4%and 33.1%, respectively, and that of group C was 34.6%and 31.3%, respectively.All patients’ hormone levels （including FSH, LH, E2 and P） reduced.Compared with the levels before treatment, the levels of E2 and P decreased significantly （ F value was 16.713 and 20.968, respectively, both P〈0.001）.There was no obvious adverse reaction in three groups.Conclusion Small dose of mifepristone has good clinical effect on the treatment of uterine fibroid.
出处
《中国妇幼健康研究》
2014年第5期826-827,849,共3页
Chinese Journal of Woman and Child Health Research
关键词
不同剂量
米非司酮
子宫肌瘤
临床疗效
different dose mifepristone uterine fibroid clinical curative effect
