摘要
目的 探讨替莫唑胺对高级别神经胶质瘤的临床治疗效果和安全性,为该类疾病的临床治疗提供方案参考.方法 选择2007年2月～2011年5月于徐州市中心医院收治的83例术后有残留灶的高级别神经胶质瘤患者,分为治疗组（42例）和对照组（41例）,其中对照组给予外科治疗和常规外放疗,治疗组则在原有治疗基础上加用替莫唑胺进行化疗,评价两组的临床疗效.结果 治疗组的近期总有效率为88.09％,对照组为60.97％,两组差异有统计学意义（P＜0.05）.治疗组患者的中位生存期（17.4个月）和1年（76.19％）、2年生存率（47.62％）均高于对照组[10.3个月、51.22％、31.71％],差异有统计学意义（P＜0.05）.对照组和治疗组在化疗2、4个疗程时的生存质量评分差异无统计学意义（P＞0.05）,但在化疗6个疗程时治疗组高于对照组,差异有统计学意义（P＜0.05）.治疗组的不良反应发生率略高于对照组,但差异无统计学意义（P＞0.05）.结论 高级别神经胶质瘤术后使用替莫唑胺进行化疗,可提高临床有效率,改善患者的生存质量,且临床安全性和耐受性良好.
Objective To investigate the clinical effect and safety of Temozolomide for the postoperative high-grade gliomas ,expected to provide a reference for the treatment of high-grade gliomas. Methods From February 2007 to May 2011, in the Central Hospital of Xuzhou City, 83 cases of patients with high-grade gliomas were selected and divided into treatment group （42 cases） and control group （41 cases）, the control group was treated with surgical treatment and conventional external radiotherapy, while the treatment group was treated with add temozolomide, the effect between the two groups was compared. Results The total effect rate of control group and treatment group was 60.97% and 88.09%, and the difference was statistically significant （P 〈 0.05）. The median survival （17.4 months）, the one year （76.19%）, two years （47.62%） survival rate of treatment group were higher than those of control group （10.3 months, 51.22%, 31.71%）, the differences were statistically significant （P 〈 0.05）. The scores of life quality after 2 courses and 4 courses were not statistically significant different between the two groups, but there was a statistically significant difference after 6 courses （P 〈 0.05）. The incidence of treatment group was higher than control group, but the difference was not statisti- cally significant （P 〉 0.05）. Conclusion Temozolomide chemotherapy can improve the clinical and the quality of life of patients of the high-grade gliomas, with good clinical safety and well-tolerated.
出处
《中国医药导报》
CAS
2014年第33期47-50,共4页
China Medical Herald
基金
江苏省徐州市科技局科技项目(编号XZZD1350)
