摘要
目的:利用静息态功能磁共振技术,比较带状疱疹急性期、后遗神经痛期不同阶段大脑神经功能学差异,通过神经影像学来描述带状疱疹引发的疼痛的发生过程,阐述大脑相应激活区域与带状疱疹后神经痛发生的相关性。方法:收集带状疱疹患者12例,其中急性期组6例,后神经痛组6例。扫描前先进行视觉模拟评分法(Visual Analogue Score,VAS)以及SF-MPQ(Short-form of McGill pain questionnaire)评分。随后分组进行fMRI静息态扫描,扫描后通过SPM、REST统计软件处理分析得到局部一致性(Regional Homogeneity,ReHo)数据统计结果。然后分别对比急性期组与后神经痛组的大脑激活区域的差异。结果:对比后神经痛组与急性期组的ReHo结果,前者较后者ReHo值升高的区域有:双侧丘脑、右侧小脑、右侧海马体、右侧梭状回、右侧脑岛。结论:小脑、脑岛、丘脑可能与PHN痛觉过敏形成机制相关;海马体可能参与疼痛记忆的形成。
Objective： To investigate the cerebral function in acute phase and PHN （post-herpetic neuralgia） phase of the herpes zoster patients using the rest state function magnetic resonance imaging （RS-fMRI） technique. The aim was to use the neuroimaging to understand the processing of the pain in herpes zoster and PHN and tried to find the connection between the brain-activated regions in PHN. Methods： Six patients with herpes zoster acute phase patients and six patients with PHN were recruited. To evaluate subjective perception of pain under both conditions, Visual Analogue Scale （ VAS ） and short-form of McGill pain questionnaire （ SF-MPQ ） scores system and fMRI scanning were used. Patients were scanned by fMRI in resting state and data were analyzed by SPM and REST softwares, then we got regional homogeneity （ReHo） data. We use those data to describe the changes of activated cerebral regions at different phases of herpes zoster. Results： The brain-activated regions in PHN patients showed a higher value of ReHo in bilateral thalamus, right cerebellum, right insula, left hippocampus, right fusiform gyrus, and right insula, compared with that of acute patients ReHo images Conclusion： Cerebellum, thalamus and insula may mediate the mechanism of PHN hyperpathia. Hippocampus may participate in the production of pain memory.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2014年第10期717-721,共5页
Chinese Journal of Pain Medicine
关键词
带状疱疹
带状疱疹后神经痛
静息态
功能磁共振成像
脑
Herpes zoster
Postherptic Neuralgia
Resting state
State function magnetic imaging
Brain
