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胃癌中p-Stat3活化和SOCS3表达的临床病理意义及其对预后的影响 被引量:8

Clinical pathological and prognostic significance of activated p-Stat3 and expressed SOCS3 in patients with gastric cancer
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摘要 目的探讨胃癌及癌旁组织中信号传导与转录激活因子3(Stat3)的活化及细胞因子信号转导抑制蛋白3(SOCS3)的表达水平对胃癌的发生、发展以及预后的影响。方法应用免疫组织化学Envision法检测53例胃癌以及其中27例相应癌旁组织中活化的Stat3(p-Stat3)的活化及SOCS3的表达水平,并结合患者的临床病理及随访资料进行分析。结果胃癌组织细胞核中p-Stat3的活化水平显著高于癌旁组织,细胞质中SOCS3的阳性表达明显低于非癌组织(P<0.05)。胃癌组织中p-Stat3活化水平与肿瘤浸润深度、分化程度和TNM分期呈明显正相关,SOCS3的表达与肿瘤浸润深度、TNM分期及淋巴结转移存在明显的负相关(P<0.05)。胃癌中p-Stat3活化水平与SOCS3表达水平呈明显负相关(r=-0.492,P<0.05)。Kaplan-Meier生存分析结果显示,p-Stat3的活化水平与患者生存率呈显著负相关(χ2=-5.05,P<0.05);相反,SOCS3表达水平则与患者生存率呈显著正相关(χ2=10.852,P<0.05)。结论 p-Stat3水平增高及负调节分子SOCS3的表达减少可能参与胃癌的发生、发展,可为评估胃癌预后的潜在临床指标。 Objective To investigate the levels of activated Stat3(p-Stat3)and the expression levels of SOCS3 as well as their clinical significance and its impact on the pathogenesis,progression,and prognosis in patients with gastric cancer.Methods The levels of p-Stat3 and SOCS3were tested in 53 cases of gastric cancer tissues(test group)and 27 cases of adjacent non cancerous tissues(control group)by immunohistochemistry(IHC).The clinical pathological and follow up data were analyzed.Results The levels of activated p Stat3 were significantly higher in gastric cancer tissues than in non cancerous tissues.The levels of SOCS3 were lower in cancer tissues than in non cancerous control tissues(P〈0.05).p-Stat3 showed significantly different levels among TNM stages and tumor differentiation,and the expression levels of SOCS3 were negatively associated with cancer invasion,lymph node metastasis and TNM stages in cancer patients(P〈0.05).Furthermore,a negative correlation was observed between the levels of activated p-Stat3 and SOCS3in gastric cancer tissues(r=-0.492,P〈0.05).Kaplan Meier survival analyses indicated that the ptat3 levels were negatively correlated with total survival of gastric cancer patients,the higher the levels of p-Stat3 was,the lower the total survival rate would be(χ2=-5.05,P〈0.05).On the contrary,the levels of SOCS3 showed a positive correlation with total survival(χ2=10.852,P〈0.05).Conclusion Increased a p-Stat3 and decreased expression of negative Stat3 regulator SOCS3may play important roles in the development and progression of gastric cancer,both of which would potentially serve as prognostic markers for gastric cancer.
出处 《重庆医学》 CAS CSCD 北大核心 2014年第32期4316-4319,共4页 Chongqing medicine
基金 新疆研究生科研创新计划(XJGRI2013066) 石河子大学绿洲学者基金(LZXZ201023)
关键词 胃肿瘤 信号传导与转录激活因子3 细胞因子信号转导抑制蛋白3 癌症发生 癌症生存 stomach neoplasms signal transducer and activator of transcription 3 suppressor of cytokine signaling 3 cancer pathogenesis cancer survival
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参考文献11

  • 1Kamran MZ, Patil P, Gude RP. Role of STAT3 in cancer metastasis and translational advances[J]. Biomed Res Int, 2013,2013:421821.
  • 2Inagaki-Ohara K, Kondo T, Ito M, et al. SOCS, inflamma- tion,and cancer[J]. JAKSTAT,2013,2(3) : e24053.
  • 3汤钊猷.现代肿瘤学[M].3版.上海:复旦大学出版社,2011:890-931.
  • 4许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231. 被引量:1368
  • 5Tye H, Kennedy CL, Najdovska M, et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis in- dependent of tumor inflammation[J]. Cancer Cell, 2012, 22(4) :466-478.
  • 6Deng J, Liang H, Zhang R, et al. STAT3 is associated with lymph node metastasis in gastric cancer[J]. Tumour Biol, 2013,34 (5) : 2791-2800.
  • 7Molavi O, Wang P, Zak Z J, et al. Gene methylation and silencing of SOCS3 in mantle cell lymphoma[J]. Br J Haemato, 2013,161 (3) : 348-356.
  • 8贾芙蓉,周劲松,张哲雄,何成彦,刘伟林,赵运,姜喜远,王凤华.SOCS-3 mRNA在胃癌组织及胃癌细胞系中的表达[J].中国实验诊断学,2006,10(5):446-448. 被引量:4
  • 9Yokogami K, Yamashita S, Takeshima H. Hypoxia-in- duced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression [J]. Brain Tumor Pathol,2013,30(3) : 135-143.
  • 10Xiong H, Du W, Wang J L, et al. Constitutive activation of STAT3 is predictive of poor prognosis in human gas- tric cancer[J]. J Mol Med (Berl), 2012,90 (9): 1037- 1046.

二级参考文献35

  • 1余祖滨,闵家新,白莉,姚珂,张国强.SOCS3基因转染对人肺腺癌细胞株A549增殖的影响[J].癌症,2004,23(9):1047-1051. 被引量:5
  • 2赵彤,朱梅刚,黄宗义,张亚历,张素娟,李梅芳.肺癌癌基因蛋白产物同步检测的对比分析[J].癌症,1995,14(1):13-15. 被引量:54
  • 3谷化平,冯和平,徐志勇,苏红.免疫组化在恶性黑色素瘤诊断中的作用[J].中国肿瘤临床,1996,23(8):599-600. 被引量:4
  • 4Ikuya Sakai,Kazuto Takeuchi,et al.Constitutive expression of SOCS3confers resistance to IFN-α in chronic myelogenous leukemia cells[J].Blood,2002,100:2926.
  • 5Brender C,Nielsen M,Kaltoft K,et al.STAT3-mediated constitutive expression of SOCS-3in cutaneous T-cell lymphoma[J].Blood.2001,97:1056.
  • 6Shen X,Hong F,Nguen V-A,Gao B.IL-10attanuares IFN-activated STAT1 in the liver:involvement of SOCS2 and SOCS3[J].FEEBS Lett.2000,480:132.
  • 7Song MM,Shuai K.The suppressor of cytokine signalng(SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiprolferative activities[J].J Biol Chen.1998,273:35056.
  • 8Ito S,Ansari P,Sakatsume M,et al.Interleukin-10 inhibits expression of both interferon-α-and interferon-γ inducedgenes by suppressing tyrosine phosphorylation of STAT1[J].Blood,1999,93:1456.
  • 9Carmen G ómez-Guerrero,Oscar López-Franco,et al.suppressors of cytokine signaling regulate Fc receptor signaling and cell activation during immune renal injury[J].The Jonrnal of Immunology,2004,172:6969.
  • 10Aaronson,D.S.& Horvath,C.M.A road map for hose who do not know JAK-STAT[J].Science,2002,296:1653.

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