摘要
目的探讨降低血尿酸(SUA)水平对高血压合并无症状高尿酸血症(HUA)患者血压控制以及肾功能的影响。方法将148例原发性高血压合并无症状HUA的患者分为治疗组及对照组,治疗组使用苯溴马隆、低嘌呤食物饮食,对照组给予安慰剂及普通饮食。两组给予降压药物治疗。观察两组患者治疗前后血压、SUA、肌酐(Cr)、肌酐清除率(Ccr)、24h尿蛋白定量(MAU)、血清β2微球蛋白(β2-MG)的变化,记录苯溴马隆不良反应的情况。结果治疗组患者经治疗后各时间点的收缩压(SBP)、舒张压(DBP)均显著下降,1个月后SUA水平较治疗前显著下降;与对照组相比,治疗组患者血压水平3个月后均显著低于对照组,SUA水平至1个月后的各时间点均显著低于对照组,血Cr、Ccr、MAU、血清β2-MG水平在3个月及6个月时均显著低于对照组(P<0.05)。结论高血压合并无症状HUA患者经降SUA治疗,能有效降低血压,保护肾功能。
Objective To investigate the effect of the reduction of serum uric acid（SUA）on blood pressure（BP）control and renal function protection in hypertensive patients with asymptomatic hyperuricemia（HUA）.Methods One hundred and forty-eight hypertensive patients with asymptomatic HUA were randomly divided into two groups,namely HUA reduction group and control group.Patients in HUA reduction group was provided with benzbromarone and low purine food,while patients in control group was given placebo and ordinary diet.All patients were given the same method of antihypertensive drugs.Follow up was preformed for 6months,data of BP,SUA,creatinine（Cr）,creatinine clearance（Ccr）,24 hmicroalbuminuria quantity（MAU）,serumβ2microglobulin（β2-MG）and adverse reactions were recorded and analyzed.Results The systolic blood pressure（SBP）and diastolic blood pressure（DBP）of patients in HUA reduction group significantly decreased immediately after being treated,while SUA decreased 1month after being treated.Compared with control group,the average SBP and DBP of patients in HUA reduction group was significantly lower 3months after being treated;the SUA was significantly lower 1months after being treated,the levels of Cr,Ccr,MAU andβ2-MG was significantly lower at 3months and 6months after being treated（P〈0.05）.Conclusion The SUA therapy can effectively lower BP and SUA levels of primary hypertensive patients with asymptomatic HUA while protecting renal function.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第32期4326-4328,共3页
Chongqing medicine
关键词
高血压
高尿酸血症
尿酸
血压
hypertension
hyperuricemia
uric acid
blood pressure
