摘要
目的研究左卡尼汀辅助治疗老年社区获得性肺炎(CAP)的疗效。方法选择我科住院的老年社区获得性肺炎患者63例,随机分为常规组33例,实验组30例,两组均给予抗感染、化痰、解痉、平喘的常规治疗,实验组加用左卡尼汀2 g/d,观察两组治疗期间的白细胞、中性粒细胞、降钙素原及C反应蛋白的变化。结果 1常规组与实验组患者在一般资料无统计学差异(P>0.05)。2治疗第4天常规组与实验组白细胞及中性粒细胞计数均明显降低(P<0.05),但实验组降低更为显著(P=0.007,P=0.004)。3实验组治疗第3天、第5天及第7天血清PCT浓度、CRP浓度与前次数据相比均有明显差异(P<0.05)。结论左卡尼汀辅助治疗老年社区获得性肺炎可增强抗炎效果,缩短抗炎疗程。
Objective To study the clinical effect of L-carnitine in the auxiliary treatment of elderly patients with community-acquired pneumonia. Methods 66 elderly patients with community-acquired pneumonia were randomly divided into two groups, 33 cases in the normal control group and 30 cases in the experimental group. Both of them were given common treatment, including anti-infection, reducing phlegm, relieving spasm and preventing asthma, and 2g of L-carnitine was given to the experimental group every day. The changes of white blood cells, neutrophile granulocyte, procalcitonin and C-reactive protein were observed. Results ① There was no statistical difference in basic clinical information between the two groups （P 〉 0. 05 ）. ② Four days after the treatment, white blood cells and neutrophil count decreased obviously in the two groups, but the decrease was more pronounced in the experimental group than in the control group （P 〈 0. 05）. ③ In the experimental group, there were significant differences in the concentration of serum PCT and CRP at the 3rd, 5th and 7th days of the treatment （P 〈 0. 05 ）. Conclusion L-carnitine can enhance anti-infection effect and shorten the period of anti-inflammatory treatment in the auxiliary treatment of elderly patients with community-acquired pneumonia.
出处
《临床肺科杂志》
2015年第1期45-48,共4页
Journal of Clinical Pulmonary Medicine
关键词
左卡尼汀
社区获得性肺炎
老年
抗炎
疗效
L-carnitine
community-acquired pneumonia
elderly
anti-infection
effect
