摘要
目的：研究便秘与结直肠癌的相关性。方法计算机检索 PubMed、MEDLINE、Cochrane library、Google scholar数据库至2014年8月1日，以获得探讨便秘与结直肠癌关系的病例对照研究和队列研究。使用Newcastle-OttawaScale（NOS）评价研究质量。采用RevMan 5.1.7软件分析数据，计算比值比（OR）及95%置信区间（95% CI），检验异质性并寻找其来源，应用漏斗图评估发表偏倚。结果共纳入11篇文献，NOS评分3～6分。5篇队列研究显示，便秘组结直肠癌发病率与非便秘组无统计学差异（OR＝0.92，95%CI：0.55，1.52）。亚组分析显示，便秘组和非便秘组不同部位结直肠癌的发病率无统计学差异（结肠癌 OR＝1.16，95% CI：0.78，1.73；直肠癌OR＝0.90，95%CI：0.38，2.10）。6篇病例对照研究提示，结直肠癌组便秘发生率与对照组无统计学差异（OR＝1.43，95%CI：0.99，2.04）。研究间存在异质性。结论病例对照研究及队列研究均提示便秘与结直肠癌无显著相关性。研究间存在异质性，有待高质量的研究进一步证实。
Objective To examine the relationship between constipation and the risk of colorectal cancer （CRC）. Methods Original case-control and cohort studies published to August 2014 were selected by literature search in the databases of PubMed, Embase, Cochrane library and Google scholar. Newcastle-Ottawa Scale （NOS） was used to define study quality. Pooled effect sizes were calculated using RevMan 5.1.7 software. Sensitivity analyses were performed to detect the potential sources of heterogeneity. Funnel plot was used to assess publication bias. Results 11 studies were identified including 5 cohort studies and 6 case-control surveys with NOS scored from 3 to 6. No significant association was found between constipation and CRC in cohort studies （OR=0.92;95%CI 0.55, 1.52）. Subgroup analysis revealed no significant association between constipation and colon cancer （OR=1.16, 95%CI 0.78, 1.73） or rectal cancer （OR=0.90, 95%CI 0.38, 2.10）. No significant association was found between constipation and CRC in case-control studies （OR=1.43, 95% CI 0.99, 2.04）. Significant heterogeneity was observed between studies. Conclusions Both Cohort and case-control studies demonstrated no significant association between constipation and CRC. Heterogeneity was observed between studies. More well designed studies are needed to confirm the conclusion.
出处
《中华临床医师杂志（电子版）》
CAS
2014年第20期35-38,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
便秘
结直肠肿瘤
META分析
Constipation
＇ Colorectal neoplasms
Meta-analysis
