摘要
目的 探讨同型半胱氨酸（HCY）、肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6与急性胰腺炎（AP）病情严重程度的相关性以及对AP患者预后的评估价值.方法 选取AP患者64例,将其分为轻症AP组41例（MAP组）、重症AP组23例（SAP）;另选取健康体检者72例作为对照组.分别于入院第1、3和7天抽取静脉血检测血清HCY、TNF-α和IL-6水平,同时进行急性生理和慢性健康评分标准Ⅱ（APACHEⅡ）评分.结果 与对照组比较,入院第1天MAP组和SAP组血清HCY、TNF-α和IL-6水平均升高（P＜0.01）,其中SAP组升高更加明显（P＜0.01）;入院第3天时MAP组和SAP组血清HCY、TNF-α和IL-α水平均明显升高达到峰值;经常规治疗后（入院第7天）,两组HCY、TNF-α和IL-6水平均明显下降.HCY、TNF-α和IL-6水平与APACHEⅡ评分呈正相关（P＜0.01）.结论 血清HCY、TNF-α和IL-6水平与AP的发生、发展相关,早期密切观察血清HCY、TNF-α和IL-6水平变化对评估AP的严重程度和判断预后有一定的临床价值.
Objective To explore the correlation of serum homocysteine （HCY） , tumor necrosis factor -α（TNF-α） ,interleukin-6（IL-6） with the severity of acute pancreatitis（AP） ,and to evaluate their value for the prognosis of this disease. Methods Sixty-four patients with AP were recruited and divided into mild AP group（41 cases,MAP） and severe AP group（23 cases,SAP）. 72 healthy subjects were recruited as controls. Serum levels of HCY ,TNF-α and IL-6 in 1 st, 3rd and 7th day of hospitalization were measured and scored according to acute physiology and chronic health evaluation Ⅱ （ APACHE Ⅱ ）. Resuits Compared with controls, serum levels of HCY,TNF-α and IL-6 increased in 1st day of hospitalization, reached to the peak in 3rd day of hospitalization in MAP and SAP group （ P 〈 0. 01 ）. After conventional treatment（7th day of admission）, serum levels of HCY, TNF-α and IL-6 decreased significantly in these two groups. Concentration of HCY, TNF-α and IL-6 were positively correlated with the score of APACHE Ⅱ （ P 〈 0.05 ）. Conclusion Serum HCY,TNF-α and IL-6 levels are closely correlated with the occurrence and development of acute pancreatitis. Early detection of HCY, TNF-α and IL-6 has clinical value for evaluating the severity and prognosis in acute pancreatitis.
出处
《临床内科杂志》
CAS
2014年第9期618-620,共3页
Journal of Clinical Internal Medicine
