摘要
为了寻求杀菌剂的新的先导化合物,用姜黄素、甲醛和仲胺发生Mannich反应得到8个新的姜黄素Mannich碱衍生物,其结构经IR,1H NMR,13C NMR, MS和元素分析所表征.初步抑菌实验结果表明,所有姜黄素Mannich碱衍生物与姜黄素对比,对枯草杆菌、金黄色葡萄球菌、大肠杆菌、青霉、黑霉有更好的抑菌效果.这些结果表明含有哌嗪环的姜黄素Mannich碱抑制霉菌的活性明显（16.88～21.34 mm）.
In order to find new lead compounds for the design of new antibacterial drugs, eight novel Mannich bases of the curcumin were synthesized for the first time by Mannich reaction of curcumin, formaldehyde and various secondary amines. All the new synthesized curcumin Mannich base compounds were characterized by 1H NMR, 13C NMR, IR, MS and elemental analysis. These curcumin Mannich bases were tested in vitro against different germ and mildew, and all of them have shown better activities than curcumin against B. subtilis, S. aureus, E. coli, A. niger, and Penicillium ch. The results showed that the curcumin Mannich bases containing piperazine ring have obvious mildew resistance （with inhibition zone of up 16.88 mm to 21.34 mm）.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第11期2345-2349,共5页
Chinese Journal of Organic Chemistry
基金
四川省乐山市科技局重点(No.08SZD092)
四川省科技厅应用基础(No.2010JY0148)
乐山师范学院(No.Z1321)资助项目~~
