摘要
目的:探讨瑞舒伐他汀钙、舒血宁注射液联合α-硫辛酸治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的疗效和安全性。方法:选择收治入中南大学职工医院铁道分院的DPN病人102例,按入院时间先后分为治疗组和对照组,每组51例。两组病人均用α-硫辛酸注射液0.6g,ivgtt,qd;治疗组加用瑞舒伐他汀钙10mg,qd,睡前口服,舒血宁注射液20ml,ivgtt,qd,共用药4周。比较治疗前后两组临床疗效及相关指标的变化。结果:治疗组与对照组总有效率分别为94.1%和68.6%,差异具有统计学非常显著性意义(P<0.01)。结论:瑞舒伐他汀钙、舒血宁注射液联合α-硫辛酸治疗DPN疗效优于单用α-硫辛酸,且无明显副作用。
Objective：To explore the efficacy and safety of rosuvastatin calcium and Shuxuening injection combined with α-thioctic acid in the treatment of diabetic peripheral neuropathies （DPN）. Methods： One hundred and two patients with DPN were divided into the treatment and control groups, each consisting of 51 patients. Both groups were given α-thioctic acid injection,0.6 g,ivgtt,qd. Patients in the treatment group were given extra rosuvastatin calcium,10 mg,qd,orally before sleep, Shuxuening injection,20 ml,ivgtt, qd, for 4 weeks. Efficacy and related indexes were compared between the two groups both before and after treatment. Results： The total effective rates of the treatment and control groups were 94.1% and 68.6% ,with significant difference （P〈0.01）. Conclusion： The efficacy of rosuvastatin calcium and Shuxuening injection combined with α-thioctic acid in the treatment of DPN was superior to that of mthioctic acid alone,and no obvious adverse reactions were observed.
出处
《药学服务与研究》
CAS
CSCD
2014年第5期386-388,共3页
Pharmaceutical Care and Research
