摘要
目的比较暖宫孕子胶囊联合克罗米芬与补佳乐联合克罗米芬治疗排卵性不孕的临床疗效。方法将120例患者随机分为3组,各40例,共监测306周期。A组单用克罗米芬,B组予补佳乐联合克罗米芬,C组予暖宫孕子胶囊联合克罗米芬,于排卵前后阴道彩超监测卵泡大小、子宫内膜厚度及内膜类型,并随访临床妊娠率。结果 3组在内膜厚度、类型、临床妊娠率等方面差异有统计学意义(P<0.05),B组和C组优于A组(P<0.05),但B组和C组之间无显著性差异。B组和C组妊娠率明显高于A组(P<0.05)。结论暖宫孕子胶囊联合克罗米芬能改善单用克罗米芬的高排卵低妊娠率现象,疗效与补佳乐联合克罗米芬相似,但无补佳乐所致雌激素相关不良反应,适用人群更广。
Objective To compare the therapeutic effects of Nuangong Yunzi Capsule combined with clomiphene and progynova combined with elomiphene in treating ovulatory infertility. Methods 120 patients with ovulatory infertility were randomly divided into 3 groups with 40 cases in each group and performed the 306 menstrual cycles monitoring. The group A was given single clomiphene,the group B took clomiphene combined with progynova and the group C was given clomiphene combined with Nuangong Yunzi Capsule. The size of ovarian follicle, endometrial thickness and type before and after ovulation were monitored by the color ultrasound and the clinical pregnancy rate was followed up. Results The size of ovarian follicle, endometrial thickness and type, and pregnancy rate had statistical differences among 3 groups（P 〈 0. 05）,the group B and C were superior to the group A（P 〈 0.05）,but the difference between the group B and C had no statistical significance. The pregnancy rate in the group B and C was significantly higher than that in the group A （P 〈 0.05）. Conclusion Nuangong Yunzi Capsule combined with clomiphene can improve the phenomenon of high ovulation and low pregnancy in single use of clomiphene, its effect is similar to that of progynova combined with elomiphene, but without estrogen related adverse reactions caused by progynova,the suitable crowd is broader.
出处
《中国药业》
CAS
2014年第22期106-108,共3页
China Pharmaceuticals
