摘要
已有大量的研究证实全身麻醉药可导致老年大鼠出现广泛的神经细胞凋亡,导致术后认知功能障碍。麻醉药对发育期大脑认知功能的影响成为目前的研究重点。依托咪酯是一种常用的静脉麻醉药,常被用于小儿手术麻醉,目前关于依托咪酯对发育期大脑认知功能的影响及其机制都尚无定论,其机制的阐明可能对临床小儿麻醉用药的安全选择起到指导意义。
Large numbers of studies have confirmed that anesthetics can cause nerve cell apoptosis in aged rats appeared widely in postoperative cognitive dysfunction.Effects of anesthetics on fast development period of the brain cognition function become a focus of research at present.Etomidate is a common intravenous anesthetic,often used in pediatric anesthesia.The effect on brain cognition function development and its mechanism are inconclusive.The security selection to clarify its mechanism may be of clinical pediatric anesthesia to guide significance.
出处
《华夏医学》
CAS
2014年第5期140-144,共5页
Acta Medicinae Sinica
基金
广西卫生厅科研项目资助(Z2012397)
广西教育厅科研项目资助(201204LX243)
