摘要
目的分析GP73及AFP在诊断HBV相关性肝病患者中的临床意义.方法选择慢性乙型肝炎患者83例(A组),乙肝肝硬化患者57例(B组),HCC患者41例(C组),分别检测GP73、AFP及肝功能相关指标.结果 B组GP73较A组增高,差异有统计学意义(P<0.05),C组AFP及GP73较A、B组均有升高,差异有统计学意义(P<0.05).B组较A组ALT、AST、CHE、ALB、TBIL均有差异,差异有统计学意义(P<0.05),C组ALP、ALT、AST、CHE、ALB、TBIL较A、B组均有差异,差异有统计学意义(P<0.05).AFP与AST、CHE呈相关(P<0.05),GP73与ALT、AST、CHE、ALB呈相关(P<0.05),与ALP、TBIL无相关性(P>0.05).结论 GP73相对于AFP是反映HBV相关性肝病患者进展重要指标,并与肝损害程度显著相关.
Objective To analyze the clinical significance of GP73 and AFP in the detection of HBV related liver disease. Methods 83 patients with chronic hepatitis B（group A）, 57 patients with liver cirrhosis caused by hepatitis B（group B）,41 patients with HCC（group C） were selected, GP73, AFP, and liver function related indicators were tested.Results The serum levels of GP73 in group B were significantly higher than group A（P0.05）. The serum levels of AFP and GP73 in group C were significantly higher than group A and B（P0.05）.The serum levels of ALT,AST,CHE,ALB,TBIL in group B were significantly higher than group A（P0.05）. The serum levels of ALP,ALT,AST,CHE,ALB,TBIL of group C were significantly higher than group A and B（P0.05）. AFP and AST, CHE were significantly correlated（P0.05）,GP73 and ALT,AST,CHE, ALB were significantly correlated（P0.05）,and ALP, TBIL did not show significant correlation（P 0.05）. Conclusion Compared with AFP,GP73 is an important index in HBV related liver disease progress,and is associated with the degree of liver damage.
出处
《昆明医科大学学报》
CAS
2014年第10期109-111,共3页
Journal of Kunming Medical University
基金
河北省科学技术计划基金资助项目(2013K9-11-94)
