摘要
目的通过建立牙周炎实验动物模型,观察二甲胺四环素胶原凝胶制剂治疗牙周炎的效果。方法56只清洁级金黄地鼠随机分成正常组、牙周炎组、实验组。正常组普通饮食,不做任何干预;牙周炎组、实验组用细线结扎实验牙的牙颈部,喂食高糖饮食,口腔接种致病菌牙龈卟啉单胞菌、中间型普里沃氏菌和巨核梭形杆菌,以形成牙周炎动物模型,实验组同时使用二甲胺四环素胶原凝胶制剂治疗金黄地鼠实验性牙周炎,观察比较3组的各项牙周指数及组织病理学变化,用以评价疗效。结果实验组用药后,菌斑指数、探诊出血、牙槽骨吸收值均优于牙周炎组,差异有统计学意义(P﹤0.01);实验组与正常组比较,菌斑指数、探诊出血差异无统计学意义(P﹥0.05),牙槽骨吸收值差异有统计学意义(P﹤0.05)。结论二甲胺四环素胶原制剂对金黄地鼠实验性牙周炎有良好的治疗作用。
Objective To evaluate the effect of the preparation of collagen gel of minocycline on experimental periodontitis. Methods A total of 56 SPF golden hamsters were divided into control group,periodontitis group and experimental group. The animals in the control group were fed with normal diet only. The animals in the periodontitis and the experimental groups were ligated with thin thread at the neck of selected teeth,fed with high-sugar diet and infected with Porphyomonas gingivalis（ P. g）,Prevotella intermedia（ P. i） and Fusobacterium nucleatum（ F. n） in the oral cavity to induce periodontitis. Meanwhile the collagen gel of minocycline was used to treat the animals in the experimental group.The changes of the periodontal index and pathology were compared among the three groups. The treatment effects were evaluated. Results The periodontal index（ plaque index,bleeding on probing and alveolar bone loss） of the treated group significantly improved compared with the periodontitis group（ P ﹤ 0. 01）. There was no significant difference in plaque index and bleeding on probing between minocycline treated group and the control group（ P ﹥ 0. 05）,but the difference in alveolar bone loss was significant（ P ﹤ 0. 05）. Conclusion The preparation of collagen gel of minocycline was effective for the treatment of experimental periodontitis in golden hamsters.
出处
《北京口腔医学》
CAS
2014年第5期264-266,共3页
Beijing Journal of Stomatology
