摘要
目的:探讨双侧原发性乳腺癌(bilateral primary breast cancer,BPBC)的临床病理特征。方法:回顾分析41例BPBC与409例单侧乳腺癌(unilateral breast cancer,UBC)的临床病理资料,应用单因素分析,分析BPBC的临床病理特点及其危险因素。结果:BPBC组中第二侧原发乳腺癌中原位癌(ductal carcinoma in situ,DCIS)的比例显著高于第一侧原发乳腺癌(17.1%∶2.4%,P=0.005)。BPBC组中一级或二级亲属患乳腺癌的比例显著高于UBC组(24.4%∶6.3%,P=0.001)。与UBC相比,BPBC组在发病年龄、肿瘤大小、临床分期、组织学分级、病理类型、分子分型、雌激素受体(estrogen receptor,ER)和孕激素受体(progesterone receptor,PR)、人表皮生长因子受体2(human epidermalgrowth factor receptor-2,HER2)、细胞增殖核抗原Ki67的表达无显著差异。8例同时性BPBC中,4例患者对侧乳腺触诊阴性,通过乳腺钼靶成像发现微小钙化进而诊断为BPBC。结论:乳腺癌家族史是BPBC明确的发病危险因素,乳腺钼靶检查有助于对侧触诊阴性的同时性BPBC的诊断。
Objective： To investigate the clinicopathologic characteristics of bilateral primary breast cancer（ BPBC）. Methods： The clinicopathological materials of 41 BPBC patients and 409 unilateral breast（ UBC） were reviewed. These data were compared between the two groups above and first and second breast carcinoma in the BPBC group by univariate analysis. The risk factor of developing BPBC was analyzed. Results： Within the BPBC group,the rate of ductal carcinoma in situ of the secondary breast cancer was significantly higher than the primary breast（ 17. 1% ∶ 2. 4%,P = 0. 005）. The proportion of the patients with first or second class breast cancer relatives was much higher in BPBC than in UBC（ 24. 4% ∶ 6. 3%,P = 0. 001）. There was no significant differences between the two groups in the following viariables： Age of onset,tumor size,TNM stage,histological grading,histopathology,molecular subtype,estrogen receptor（ ER） / progesterone receptor（ PR）,human epidermal growth factor receptor- 2（ HER2）and Ki67. Among 8 patients with synchronal BPBC,4 patients with impalpable contralateral breast tumor were diagnosed by mammographic microcalcifications. Conclusion： The family history of breast cancer is definitive risk factor of BPBC,mammography is helpful for the diagnosis of impalpable contralateral breast cancer lesion with synchronal BPBC.
出处
《现代肿瘤医学》
CAS
2014年第12期2859-2863,共5页
Journal of Modern Oncology
关键词
双侧原发乳腺癌
临床病理特点
危险因素
免疫组化
bilateral primary breast cancer
pathologic characteristics
risk factors
immunohistochemistry
