摘要
目的 探讨不同年龄段非控制失血性休克模型大鼠在限制性液体复苏时的最佳复苏压力.方法 采用断尾的方法制备未控制创伤失血性休克大鼠模型,按年龄段分为未成年组（6周龄）、成年组（16周龄）及老年组（12月龄）,每组按限制性液体复苏水平随机分配为未治疗组,40 ～ 50 mmHg组,＞50 ～ 60 mmHg组,＞60 ～ 70 mmHg组,每组8只.记录各组大鼠的存活时间及24 h存活率;比较各组在限制性液体复苏期间达到目标复苏压力所需的补液量及在造模90 min的血气分析、血乳酸和红细胞压积（Hct）水平.结果 不同的年龄段有不同的最佳复苏压力,6周龄组为40～ 50 mmHg,16周龄组为＞50～60 mmHg,12月龄组为＞60～ 70 mmHg.理想复苏压力下有更好的生存率及更低的血乳酸值（P＜0.01或P＜0.05）.结论 对于非控制性失血性休克,不同年龄段的最佳复苏压力目标有所不同.
Objective To explore the ideal resuscitation pressure for uncontrolled hemorrhagic shock in different ages of rats.Methods Ninety-six rats were divided into 3 groups by ages （6 weeks,16 weeks and 12 months representing pre-adult,adult and elderly rats,respectively）.Uncontrolled hemorrhagic-shock model was established in all rats.Then every group was divided into 4 groups by the different target pressures （untreated group,40 ～ 50 mmHg group,〉 50 ～ 60 mmHg group,and 〉 60 ～ 70 mmHg group）.We recorded the survival time and 24 h survival rate of rats in each group and compared the blood gas analysis,blood lactate and hematocrit （Hct） level in each group at 90 min of establishing model.Results Different ages had different optimal recovery pressure.The optimal target resuscitation pressures for 6 weeks,16 weeks and 12 months rats were 40 ～50 mmHg,〉 50 ～ 60 mmHg and 〉 60 ～ 70 mmHg,respectively.Under the ideal pressure they had a better survival rate and lower blood lactate level （P 〈 0.01 or P 〈 0.05）.Conclusious Hemorrhagic-shock rats at different ages have different ideal target resuscitation pressures during active hemorrhage.
出处
《中国医师杂志》
CAS
2014年第10期1370-1373,共4页
Journal of Chinese Physician
关键词
复苏术
疾病模型
动物
休克
出血性/治疗
血压
大鼠,Sprague-Dawley
Rats,Sprague-Dawley
Resuscitation
Disease models,animal
Shock,hemorrhagic/therapy
Blood pressure
